35843-75-5Relevant academic research and scientific papers
Copper(II) acetate/oxygen-mediated nucleophilic addition and intramolecular C-H activation/C-N or C-C bond formation: One-pot synthesis of benzimidazoles or quinazolines
He, Hua-Feng,Wang, Zhi-Jing,Bao, Weiliang
supporting information; experimental part, p. 2905 - 2912 (2010/12/29)
Diarylcarbodiimides or benzylphenylcarbodiimides are converted to 1,2-disubstituted benzimidazoles or 1,2-disustituted quinazolines via addition/intramolecular C-H bond activation/C-N or C-C bond forming reaction using copper(II) acetate/oxygen [Cu(OAc)2/O2] as the oxidant at 100°C in one-pot cascade procedure. Copyright
Selective synthesis of 4-alkylidene-β-lactams and N,N′- diarylamidines from azides and aryloxyacetyl chlorides via a ketenimine-participating one-pot cascade process
Yang, Yun-Yun,Shou, Wang-Ge,Hong, Deng,Wang, Yan-Guang
, p. 3574 - 3577 (2008/09/20)
(Chemical Equation Presented) A one-pot cascade approach to 4-alkylidene-β-lactams and N,N-diarylamidines from aryl azides and aryloxyacetyl chlorides has been developed. The chemical outcome of the reaction can be controlled selectively by an appropriate choice of the stoichiometric ratio of different substrates and reagents. The products should find use in pharmaceutical discovery, especially in the development of new antimicrobial agents against multidrug-resistant pathogens.
