358629-51-3

Usage

Uses

Used in Pharmaceutical Industry:
Methyl (2S)-2-(2-oxopyrrolidin-1-yl)butanoate is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of compounds with diverse therapeutic properties. Its role in creating new drugs is significant due to its structural compatibility with a range of biological targets.
Used in Agrochemical Industry:
In the agrochemical sector, methyl (2S)-2-(2-oxopyrrolidin-1-yl)butanoate is utilized as a precursor in the production of bioactive compounds, potentially leading to the development of new pesticides or herbicides. Its chemical properties allow for the creation of molecules that can effectively address agricultural challenges.
Used in Biotechnology Industry:
Methyl (2S)-2-(2-oxopyrrolidin-1-yl)butanoate is employed as a versatile precursor in biotechnological applications, where it is used to synthesize compounds with potential applications in genetic research, protein engineering, and the development of novel biotherapeutics. Its adaptability in molecular construction makes it a valuable asset in advancing biotechnological solutions.
Overall, the applications of methyl (2S)-2-(2-oxopyrrolidin-1-yl)butanoate span across multiple industries, highlighting its importance as a chemical building block with the potential to contribute to the creation of innovative products and solutions.

Upstream product

• 67-56-1 methanol 
• 102849-49-0 (2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid 
• 616-45-5 2-pyrrolidinon 
• 199679-81-7 (R)-2-trifluoromethanesulfonyloxybutyric acid methyl ester 
• 358629-41-1 (Z)-methyl 2-(2-oxopyrrolidin-1-yl)-2-butenoate 
• 497250-64-3 ethyl-(S)-4-[(1-methoxycarbonyl)propylamino]butyrate 
• 943986-68-3 (S)-methyl-4-(1-methoxycarbonylpropylamino)butyrate 

Downstream Products

• 102767-28-2 levetiracetam 

Relevant academic research and scientific papers

A Short Enantioselective Synthesis of (S)-Levetiracetam through Direct Palladium-Catalyzed Asymmetric N -Allylation of Methyl 4-Aminobutyrate

An exceedingly short and enantioselective synthesis of the antiepileptic drug (S)-levetiracetam was elaborated. As the chirogenic key step, a Pd-catalyzed asymmetric N -allylation of methyl 4-aminobutyrate was achieved in the presence of only 1 mol% of a catalyst prepared in situ from [Pd(allyl)Cl] 2 and a tartaric acid-derived C 2 -symmetric diphosphine ligand.

Enantioselective access to chiral drugs by using asymmetric hydrogenation catalyzed by Rh(P-OP) complexes

P-OP art: Rhodium complexes of P-OP ligands serve as highly efficient and enantioselective catalysts in asymmetric hydrogenation leading to various valuable pharmaceutical building blocks and several direct precursors of chiral drugs such as LY2497282, la

Process for the preparation of Levetiracetam

A process for the manufacturing of levetiracetam, wherein said process comprises the steps of: (1) reacting the (?)-(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid with a substoichiometric amount of an activating agent in an alcoholic solvent, and (2) subjecting the resulting reaction solution of step (1) to an ammonolysis process with gaseous ammonia.

Enantioselective hydrogenation catalysis aided by a σ-bonded calix[4]arene to a p-chirogenic aminophosphane phosphinite rhodium complex

The first P-chirogenic aminophosphane-phosphinite (AMP*P) ligand (4a) supported on the upper rim of a calix[4]arene moiety was synthesized in two steps using the ephedrine methodology. Ligand 4a was used for the preparation of the corresponding rhodium co

PROCESS FOR THE PREPARATION OF LEVETIRACETAM

The present invention relates to a process for the preparation of levetiracetam and, more particularly, to an improved process for the preparation of levetiracetam characterized by a crystallization-induced dynamic resolution of a diastereoisomeric mixture of an (±)-alpha-ethyl-2-oxo-l -pyrrolidine acetamide derivative.

Process for the preparation of 2-oxo-1-pyrrolidine derivatives

The present invention relates to alternative processes for the preparation of 2-oxo-1-pyrrolidine derivatives of formula (I) Particularly, the present invention relates to alternative processes for the synthesis of levetiracetam, brivaracetam and seletracetam.

Amino acid esters and amides for reductive amination of mucochloric acid: Synthesis of novel γ-lactams, short peptides and antiseizure agent Levetiracetam (Keppra)

A simple methodology utilizing mucochloric acid and different α- and β-amino acid esters, amides and short peptides for the synthesis of novel γ-lactam and γ-lactam-based short peptides was developed. The synthesis of an antiseizure agent, Levetiracetam (Keppra) was demonstrated. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Hydrogenation catalysts

A catalyst comprising a chiral transition metal-(1,2-bis(2,5-dialkylphospholano) complex immobilised on a specific zeolitic support useful for the hydrogenation of prochiral substrates.