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Usage

Uses

Used in Pharmaceutical Synthesis:
N-propylcyclohexanamine hydrochloride is used as a key intermediate in the synthesis of (R)and (S)-rasagiline, which are important drugs for the treatment of Parkinson's disease. N-propylcyclohexanamine hydrochloride plays a crucial role in the reductive amination process, allowing for the selective formation of the desired enantiomers with high purity and yield.

Upstream product

• 107-10-8 propylamine 
• 108-93-0 cyclohexanol 
• 108-94-1 cyclohexanone 
• 108-91-8 cyclohexylamine 
• 925-90-6 ethylmagnesium bromide 
• 126541-65-9 N-(benzotriazol-1-yl-methyl)-cyclohexylamine 

Relevant academic research and scientific papers

Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing

The reductive aminase from Aspergillus oryzae (AspRedAm) was combined with a single alcohol dehydrogenase (either metagenomic ADH-150, an ADH from Sphingobium yanoikuyae (SyADH), or a variant of the ADH from Thermoanaerobacter ethanolicus (TeSADH W110A)) in a redox-neutral cascade for the biocatalytic alkylation of amines using primary and secondary alcohols. Aliphatic and aromatic secondary amines were obtained in up to 99 % conversion, as well as chiral amines directly from the racemic alcohol precursors in up to >97 % ee, releasing water as the only byproduct.

The N-Substitution of Aliphatic Primary Amines via 1-benzotriazoles: Preparation of Secondary Amines

A new method has been developed for the selective conversion of primary aliphatic amines into unsymmetrical secondary amines by Grignard reaction of 1-benzotriazoles 1.This method employs simple procedures and mild conditions, and is specific in that onyl monoalkylation of the primary amines results.