35923-46-7

Upstream product

• 1428781-52-5 3-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)prop-2-yn-1-one 
• 146652-97-3 4-(trifluoromethyl)phenyl 4-fluorobenzyl ketone 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 455-18-5 4-CF₃C₆H₄CN 

Downstream Products

• 1594937-33-3 4-(tert-butyldimethylsilylperoxy)-4-(4-fluorophenyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-4H-isoimidazole 
• 1594937-22-0 5-(4-fluorophenyl)-2-phenyl-4-[4-(trifluoromethyl)phenyl]imidazole 

Relevant academic research and scientific papers

Copper/Iodine-Cocatalyzed C-C Cleavage of 1,3-Dicarbonyl Compounds Toward 1,2-Dicarbonyl Compounds

A new, general oxidative route to transformations of 1,3-dicarbonyl compounds to 1,2-dicarbonyl compounds by merging copper and I2 catalysis is described. This method is applicable to broad 1,3-dicarbonyl compounds, including 1,3-diketones, 1,3-keto esters and 1,3-keto amides. Mechanistical studies show that the reaction is achieved via the C–C bond cleavage and CO release cascades.

Dimethyl Sulfoxide as an Oxygen Atom Source Enabled Tandem Conversion of 2-Alkynyl Carbonyls to 1,2-Dicarbonyls

A tandem transformation of 2-alkynyl carbonyl compounds by means of a CuBr2/I2/DMSO/water system is developed, enabling the fromation of various functionalized 1,2-dicarbonyl compounds, including 1,2-diketones, α-keto amides and α-keto ester. This Cu-promoted iodine-mediated tandem procedure employs DMSO as the oxygen atom source of the formed carbonyl group through iodonium ion formation, nucleophilic DMSO addition and C?C bond cleavage cascades. (Figure presented.).

The chemiexcitation of the chemiluminescence of lophine peroxide anions via a partially cyclic transition state

It was shown that acyclic intermediates play a role in the chemiexcitation of the chemiluminescence (CL) of lophine peroxides in addition to the dioxetane intermediates. Because the CL efficiencies of position-isomers (R)-9 and (R)-10, which theoretically give the common dioxetane intermediate, were different, the different CL efficiencies are attributable to the CL mechanism involving a partially cyclic transition structure at the chemiexcitation step. The study of isomeric 2-phenyl-4-p-X-phenyl-5-p-Y-phenyl-4-silylated peroxy-isoimidazals [(R)-9: X = CF3, Y = F and (R)-10: X = F, Y = CF3] confirmed the existence of lophine peroxide anion intermediates in the chemiluminescence of lophine peroxides in addition to the dioxetane intermediates. Copyright

Practical method for transforming alkynes into α-diketones

Oxidation of alkynes to α-dicarbonyl derivatives through a convenient one-pot procedure via a Bronsted acid-promoted "hydration" and a DMSO-based oxidation sequence has been achieved in high yields, The scope and limitations of the reaction have also been investigated.