35924-44-8

Basic information

• Product Name: 6-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID
• Synonyms: 6-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID;AKOS BBS-00007908;AURORA 12210;6-methoxy-2-oxo-2H-1-benzopyran-3-carboxylic acid
• CAS NO: 35924-44-8
• Molecular Formula: C₁₁H₈O₅
• Molecular Weight: 220.18
• Mol File: 35924-44-8.mol
• Article Data: 28

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID(35924-44-8)
• EPA Substance Registry System: 6-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID(35924-44-8)

Safety Data

• Hazardous Substances Data: 35924-44-8(Hazardous Substances Data)

Upstream product

• 89228-62-6 N-hydroxy-6-methoxy-2-oxo-2H-1-benzopyran-3-carboxamide 
• 117646-10-3 5-(2',5'-dimethoxybenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 141-82-2 malonic acid 
• 2033-24-1 cycl-isopropylidene malonate 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 41459-71-6 ethyl 6-methoxycoumarin-3-carboxylate 
• 682805-95-4 2,4-dimethoxybenzylidenemalonic acid 
• 150-76-5 4-methoxy-phenol 
• 105-53-3 diethyl malonate 
• 133031-78-4 dipotassium 2,4-dimethoxybenzylidenemalonate 
• 7324-86-9 ethyl 3-(2,4-dimethoxyphenyl)-2-ethoxycarbonyl-2-propenoate 
• 17580-69-7 2-hydroxy-5-methoxybenzaldehyde oxime 

Relevant articles and documents

Method for synthesizing coumarin-3-carboxylic acid compounds by one-pot two-step method

The invention relates to a method for synthesizing coumarin-3-carboxylic acid compounds by a one-pot two-step method. The structural formula of the coumarin-3-carboxylic acid compounds is shown in the description, wherein R1 is H , Cl , Br, NO2 , CH3 and HO . According to the synthesis process of the coumarin-3-carboxylic acid compounds, malonic acid, acetone and substituted salicylaldehyde serve as raw materials, iodine serves as a catalyst, acetic anhydride serves as a solvent, a series of coumarin-3-carboxylic acid compounds are synthesized through a one-pot cascade reaction, and the efficiency and the yield are greatly improved compared with a fractional step method.

3 - Coumarin formic acid compound and application thereof as antibacterial agent for preparing plant pathogenic bacteria

The invention relates to a compound with simple structure for inhibiting growth activity of phytopathogens, specifically relates to a 3-coumarin formic acid compound and application of the 3-coumarin formic acid compound as an antibacterial agent for preparing the phytopathogens, and discloses application of the 3-coumarin formic acid compound as the antibacterial agent for preparing the phytopathogens. The two 3-coumarin formic acid compounds has the following characteristics of molecular structure: the formulas are as shown in the specification, wherein R is hydrogen, methyl, methoxyl, hydroxyl, halogen and nitryl. The in vitro inhibitory activity of twenty-eight synthetic target compounds on four common plant pathogenic fungi such as apple decay pathogenic bacteria, apple ring spot pathogenic bacteria, maize curvularia pathogenic bacteria and potato dry rot pathogenic bacteria is measured by adopting a hypha linear growth rate method, so that the condition that all compounds have different inhibiting effects on supplied experimental bacteria is found.

Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity

A series of (3-hydroxypyridin-4-one)-coumarin hybrids were developed and investigated as potential multitargeting candidates for the treatment of Alzheimer's disease (AD) through the incorporation of iron-chelating and monoamine oxidase B (MAO-B) inhibition. This combination endowed the hybrids with good capacity to inhibit MAO-B as well as excellent iron-chelating effects. The pFe3+ values of the compounds were ranging from 16.91 to 20.16, comparable to more potent than the reference drug deferiprone (DFP). Among them, compound 18d exhibited the most promising activity against MAO-B, with an IC50 value of 87.9 nM. Moreover, compound 18d exerted favorable antioxidant activity, significantly reversed the amyloid-β1-42 (Aβ1-42) induced PC12 cell damage. More importantly, 18d remarkably ameliorated the cognitive dysfunction in a scopolamine-induced mice AD model. In brief, a series of hybrids with potential anti-AD effect were successfully obtained, indicating that the design of iron chelators with MAO-B inhibitory and antioxidant activities is an attractive strategy against AD progression.