35943-98-7Relevant articles and documents
Applicability of aluminum amalgam to the reduction of arylnitro groups
Luzzio, Frederick A.,Monsen, Paige J.
supporting information, (2020/11/02)
An array of arylnitro compounds with various functionality were treated with freshly-prepared aluminum amalgam in THF/water solution and resulted in the corresponding arylamines. The Al(Hg)-mediated reductions are relatively rapid with consumption of the amalgam and disappearance of starting material occurring over 20–30 min. The workup of the reductions involves only removal of the insoluble by-products by filtration followed by concentration. Only in some cases is chromatography required to secure the pure product. The desired arylamines are furnished in quantities of 25–100 mg, which in some cases, could be taken on to the next reaction without further purification. Reductions of 4-nitrobenzyl derivatives of carbohydrates or nucleosides were selective in affording the corresponding 4-aminobenzyl products. To show applicability in click chemistry, selected aminobenzyl products are directly azidated to yield products that were then used in click reactions to afford the corresponding 1,2,3-triazoles.
Direct N-H/ N-Me Aziridination of Unactivated Olefins Using O-(Sulfonyl)hydroxylamines as Aminating Agents
Sabir, Shekh,Pandey, Chandra Bhan,Yadav, Ajay K.,Tiwari, Bhoopendra,Jat, Jawahar L.
, p. 12255 - 12260 (2018/09/27)
Unactivated aziridines are the core substructures in a plethora of bioactive natural products and serve as building blocks in organic synthesis. Despite this, very limited methods are available to access them directly from olefins, as most of the known me
Enantioselective total synthesis of (-)-walsucochin B
Xu, Shiyan,Gu, Jixiang,Li, Huilin,Ma, Donghui,Xie, Xingang,She, Xuegong
supporting information, p. 1996 - 1999 (2014/05/06)
The first enantioselective total synthesis of the structurally unique nortriterpenoid (-)-walsucochin B has been accomplished through the cationic polyolefin cyclization initiated by chiral epoxide. The core framework and the stereocenters in the natural