35981-67-0

Upstream product

• 35981-66-9 (4-Bromomethyl-phenyl)-cyclopropyl-methanone 
• 1643-19-2 tetrabutylammomium bromide 
• 108-88-3 toluene 
• 7143-76-2 cyclopropyl-p-tolyl-methanone 
• 143-33-9 sodium cyanide 

Downstream Products

• 169280-06-2 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile 
• 50829-28-2 2,3-Bis-(4-cyclopropanecarbonyl-phenyl)-propionic acid 
• 50664-69-2 Isopropyl-p-(cyclopropylcarbonyl)phenylacetat 
• 35982-03-7 Methyl-p-(cyclopropylcarbonyl)-hydratropat 
• 35982-02-6 4-(cyclopropylcarbonyl)-benzeneacetic acid,methyl ester 
• 35982-04-8 2-(4-cyclopropanecarbonyl-phenyl)-propionic acid 
• 35981-70-5 (α-Cyclopropyl-α-hydroxy-p-tolyl)essigsaeure 
• 50664-68-1 (4-Cyclopropanecarbonyl-phenyl)-acetamide 
• 35981-81-8 p-(Cyclopropylmethyl)-hydratropinsaeure 
• 50664-66-9 p-(Cyclopropylhydroxymethyl)-phenethyl-alkohol 
• 35981-97-6 p-(Cyclopropylmethyl)phenaethyl-alkohol 
• 35981-69-2 (α-Cyclopropyl-p-tolyl)essigsaeure 
• 35981-68-1 (4-Cyclopropanecarbonyl-phenyl)-acetic acid 

Relevant academic research and scientific papers

Mild Ring Contractions of Cyclobutanols to Cyclopropyl Ketones via Hypervalent Iodine Oxidation

An iodine-mediated oxidative ring contraction of cyclobutanols has been developed. The reaction allows the synthesis of a wide range of aryl cyclopropyl ketones under mild and eco-friendly conditions. A variety of functional groups including aromatic or alkyl halides, ethers, esters, ketones, alkenes, and even aldehydes are nicely tolerated in the reaction. This is in contrast with traditional synthetic approaches for which poor functional group tolerance is often a problem. The practicality of the method is also highlighted by the tunability of iodine oxidation system. Specifically, combining the iodine(III) reagent with an appropriate base allows the reaction to accommodate a range of challenging electron-rich arene substrates. The facile scalability of this reaction is also exhibited herein. (Figure presented.).

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula whereinW represents —C(=O)— or —CH(OH)—;R1 represents hydrogen or hydroxy;R2 represents hydrogen;R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2;n is an integer of from 1 to 5;m is an integer 0 or 1;R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; andpharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —CH(OH)—; R1represents hydrogen or hydroxy; R2represents hydrogen; R1and R2taken together form a second bond between the carbon atoms bearing R1and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1and R2are taken together to form a second bond between the carbon atoms bearing R1and R2or where R1represented hydroxy, m is an integer 0.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents -C(=O)- or -CH(OH)-; R1 represents hydrogen or hydroxy; R2 represents hydrogen; R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3 is -COOH or -COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are ta to form a second bond between the carbon R1 and R2 or where R1 represented hydroxy integer 0.