35982-99-1

Basic information

• Product Name: 2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE
• Synonyms: IFLAB-BB F2113-0023;2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE
• CAS NO: 35982-99-1
• Molecular Formula: C₁₂H₆Cl₂N₂
• Molecular Weight: 249.1
• Mol File: 35982-99-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 182-184°C
• Boiling Point: 402°Cat760mmHg
• Flash Point: 196.9°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 1.13E-06mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: 2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE(35982-99-1)
• EPA Substance Registry System: 2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE(35982-99-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 35982-99-1(Hazardous Substances Data)

Usage

General Description

2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE is a chemical compound with the molecular formula C12H6Cl2N2. It is a chlorinated derivative of nicotinonitrile, with two chlorine atoms attached to the carbon atoms in the aromatic ring. 2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is mainly employed in the production of various pyridine derivatives, which have a wide range of applications, including as pesticides, herbicides, and pharmaceuticals. Additionally, it can also be used in organic synthesis and as a building block in the production of other organic compounds. However, it is important to handle this chemical with caution, as it can be toxic and harmful if not properly handled and disposed of.

InChI:InChI=1/C12H6Cl2N2/c13-11-3-1-8(2-4-11)10-5-9(6-15)12(14)16-7-10/h1-5,7H

Upstream product

• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 1336-21-6 ammonium hydroxide 
• 35982-98-0 5-(4-chlorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarbonitrile 
• 1878-66-6 4-chlorophenylacetic Acid 

Relevant articles and documents

Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type i positive allosteric modulators of α7 nicotinic acetylcholine receptors

A series of novel arylpyrid-3-ylmethanones (7a-aa) were designed as modulators of α7 nicotinic acetylcholine receptors (nAChRs). The methanones were found to be type I positive allosteric modulators (PAMs) of human α7 nAChRs expressed in Xenopus ooctyes. Structure-activity relationship (SAR) studies resulted in the identification of compound 7v as a potent and efficacious type I PAM with maximum modulation of a nicotine EC 5 response of 1200% and EC50 = 0.18 μM. Compound 7z was active in reversing the effect of scopolamine in the novel object recognition (NOR) paradigm with a minimum effective ip dose of 1.0 mg/kg (2.7 μmol/kg). This effect was blocked by the selective α7 nAChR antagonist methyllycaconitine (MLA). These compounds are potent type I positive allosteric modulators of α7 nAChRs that may have therapeutic value in restoring impaired sensory gating and cognitive deficits in schizophrenia and Alzheimer's disease.