958237-61-1Relevant academic research and scientific papers
Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3 H)-ones: Effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes
Rotili, Dante,Tarantino, Domenico,Nawrozkij, Maxim B.,Babushkin, Alexandre S.,Botta, Giorgia,Marrocco, Biagina,Cirilli, Roberto,Menta, Sergio,Badia, Roger,Crespan, Emmanuele,Ballante, Flavio,Ragno, Rino,Esté, José A.,Maga, Giovanni,Mai, Antonello
, p. 5212 - 5225 (2014/07/08)
A comparison of the effects of the 6-(2-chloro-6-fluorobenzyl)-2- (alkylthio)pyrimidin-4(3H)-ones (2-Cl-6-F-S-DABOs) 7-12 and the related 6-(2,6-difluorobenzyl) counterparts 13-15 in HIV-1 infected cells and in the HIV-1 reverse transcriptase (RT) assays
Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors
Sbardella, Gianluca,Mai, Antonello,Bartolini, Sara,Castellano, Sabrina,Cirilli, Roberto,Rotili, Dante,Milite, Ciro,Santoriello, Marisabella,Orlando, Serena,Sciamanna, Ilaria,Serafino, Annalucia,Lavia, Patrizia,Spadafora, Corrado
scheme or table, p. 5927 - 5936 (2011/10/09)
A series of 5-alkyl-2-(alkylthio)-6-(1-(2,6-difluorophenyl)propyl)-3,4- dihydropyrimidin-4(3H)-one derivatives (3a-h) belonging to the F 2-DABOs class of non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) are endowed with a strong a
Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains
Mai, Antonello,Artico, Marino,Rotili, Dante,Tarantino, Domenico,Clotet-Codina, Imma,Armand-Ugón, Mercedes,Ragno, Rino,Simeoni, Silvia,Sbardella, Gianluca,Nawrozkij, Maxim B.,Samuele, Alberta,Maga, Giovanni,Esté, José A.
, p. 5412 - 5424 (2008/03/13)
Following the disclosure of dihydro-alkoxy-, dihydro-alkylthio-, and dihydro-alkylamino-benzyl-oxopyrimidines (DABOs, S-DABOs, and NH-DABOs) as potent and selective anti-HIV-1 agents belonging to the non-nucleoside reverse transcriptase inhibitor (NNRTI)
Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: Synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants
Mugnaini, Claudia,Alongi, Maddalena,Togninelli, Andrea,Gevariya, Harsukh,Brizzi, Antonella,Manetti, Fabrizio,Bernardini, Cesare,Angeli, Lucilla,Tafi, Andrea,Bellucci, Luca,Corelli, Federico,Massa, Silvio,Maga, Giovanni,Samuele, Alberta,Facchini, Marcella,Clotet-Codina, Imma,Armand-Ugón, Mercedes,Esté, José A.,Botta, Maurizio
, p. 6580 - 6595 (2008/04/12)
A series of novel S-DABO analogues, characterized by different substitution patterns at positions 2, 5, and 6 of the heterocyclic ring, were synthesized in a straightforward fashion by means of parallel synthesis and evaluated as inhibitors of human immun
