3604-17-9Relevant articles and documents
Structure-dependent selective O- or C-trifluoroethylation of 1,3-dicarbonyls by mesityl(2,2,2-trifluoroethyl)iodonium triflate
Zhao, Cheng-Long,Yang, Jing,Han, Zhou-Zhou,Zhang, Cheng-Pan
supporting information, p. 23 - 30 (2017/10/30)
Reaction of [ArICH2CF3][OTf] with structurally diversified 1,3-dicarbonyls and an appropriate base at room temperature gave O-trifluoroethylated products, C-trifluoroethylated products, or a mixture of O- and C-trifluoroethylated products in good yields. The product type was dramatically dependent upon the structure of the starting 1,3-dicarbonyls in this reaction. The cyclic 1,3-diketones exclusively afforded the O-trifluoroethylated products, whereas the acyclic 1,3-diketones, β-keto esters, and malonates selectively or specifically formed the C-trifluoroethylated products. Li2CO3 facilitated the C-trifluoroethylation of acyclic 1,3-diketones and β-keto esters. The reaction proceeded under mild conditions, without pre-activation of 1,3-dicarbonyls and use of strong base, and demonstrated a catalyst-free structure-dependent regioselective trifluoroethylation of 1,3-dicarbonyls by mesityl(2,2,2-trifluoroethyl)iodonium triflate.
CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS
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Paragraph 0063, (2015/03/16)
Cyclic vinylogous amides of Formula (I) are disclosed. The compounds are useful for treating diseases that arise from inappropriate activity of proteins containing an acetyl-lysine. The compositions comprise a genus of cyclic vinylogous amides that are in
PROSTANOIDS. XXXVI. PROSTANOID SYNTHONS BASED ON 5,5-DIMETHOXYTETRACHLOROCYCLOPENTADIENE
Tolstikov, G. A.,Ismailov, S. A.,Velder, Ya. L.,Miftakhov, M. S.
, p. 72 - 78 (2007/10/02)
Conditions are developed for the partial and exhaustive reductive dechlorination of 2,3,5-trichloro-4,4-dimethoxy-5-allyl(benzyl)-2-cyclopentenones by means of the zinc-methanol, zinc-acetic acid, and zinc-methanol-ammonium chloride system.The thermodynam
