3604-17-9Relevant academic research and scientific papers
Structure-dependent selective O- or C-trifluoroethylation of 1,3-dicarbonyls by mesityl(2,2,2-trifluoroethyl)iodonium triflate
Zhao, Cheng-Long,Yang, Jing,Han, Zhou-Zhou,Zhang, Cheng-Pan
supporting information, p. 23 - 30 (2017/10/30)
Reaction of [ArICH2CF3][OTf] with structurally diversified 1,3-dicarbonyls and an appropriate base at room temperature gave O-trifluoroethylated products, C-trifluoroethylated products, or a mixture of O- and C-trifluoroethylated products in good yields. The product type was dramatically dependent upon the structure of the starting 1,3-dicarbonyls in this reaction. The cyclic 1,3-diketones exclusively afforded the O-trifluoroethylated products, whereas the acyclic 1,3-diketones, β-keto esters, and malonates selectively or specifically formed the C-trifluoroethylated products. Li2CO3 facilitated the C-trifluoroethylation of acyclic 1,3-diketones and β-keto esters. The reaction proceeded under mild conditions, without pre-activation of 1,3-dicarbonyls and use of strong base, and demonstrated a catalyst-free structure-dependent regioselective trifluoroethylation of 1,3-dicarbonyls by mesityl(2,2,2-trifluoroethyl)iodonium triflate.
Ruthenium-catalysed C-alkylation of 1,3-dicarbonyl compounds with primary alcohols and synthesis of 3-keto-quinolines
Cini, Elena,Petricci, Elena,Truglio, Giuseppina I.,Vecchio, Marialaura,Taddei, Maurizio
, p. 31386 - 31390 (2016/04/09)
The mono-alkylation of 1,3-diketones using alcohols is possible in the presence of catalytic amounts of Ru(CO)(PPh3)3HCl and 10% mol of the Hantzsch ester. The borrowing hydrogen process between the catalyst and the dihydropyridine/p
CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS
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Paragraph 0063, (2015/03/16)
Cyclic vinylogous amides of Formula (I) are disclosed. The compounds are useful for treating diseases that arise from inappropriate activity of proteins containing an acetyl-lysine. The compositions comprise a genus of cyclic vinylogous amides that are in
Direct amino acid-catalyzed cascade biomimetic reductive alkylations: Application to the asymmetric synthesis of Hajos-Parrish ketone analogues
Ramachary, Dhevalapally B.,Kishor, Mamillapalli
supporting information; experimental part, p. 4176 - 4187 (2009/02/07)
A direct amino acid-catalyzed chemo- and enantioselective process for the double cascade synthesis of highly substituted 2-alkyl-cyclopentane-1,3-diones, 2-alkyl-3-methoxy-cyclopent-2-enones and Hajos-Parrish (H-P) ketone analogs is presented via reductive alkylation chemistry. For the first time, we have developed a single-step alkylation of cyclopentane-1,3-dione with aldehydes/ketones and a Hantzsch ester through an organocatalytic reductive alkylation strategy. A direct combination of amino acid-catalyzed cascade olefination-hydrogenation and cascade Robinson annulations of cyclopentane-1,3-dione, aldehydes/ketones, a Hantzsch ester and methyl vinyl ketone furnished the highly functionalized H-P ketone analogues in good to high yields and with excellent enantioselectivities. Many of the reductive alkylation products have shown direct applications in pharmaceutical chemistry.
PROSTANOIDS. XXXVI. PROSTANOID SYNTHONS BASED ON 5,5-DIMETHOXYTETRACHLOROCYCLOPENTADIENE
Tolstikov, G. A.,Ismailov, S. A.,Velder, Ya. L.,Miftakhov, M. S.
, p. 72 - 78 (2007/10/02)
Conditions are developed for the partial and exhaustive reductive dechlorination of 2,3,5-trichloro-4,4-dimethoxy-5-allyl(benzyl)-2-cyclopentenones by means of the zinc-methanol, zinc-acetic acid, and zinc-methanol-ammonium chloride system.The thermodynam
