360559-05-3Relevant articles and documents
Metal-catalysed radical cyclisations leading to N-heterocycles: New approaches to gabapentin and pulchellalactam
Bryans, Justin S.,Chessum, Nicola E.A.,Huther, Nathalie,Parsons, Andrew F.,Ghelfi, Franco
, p. 6221 - 6231 (2007/10/03)
The copper(I) or ruthenium(II)-mediated radical cyclisation of halo-amides has been utilised to afford functionalised pyrrolidinones via 5-endo-trig or 5-exo-trig radical cyclisation pathways. This methodology has been applied to novel and concise syntheses of the anti-epileptic drug gabapentin and the biologically active natural product pulchellalactam.