360566-30-9

Upstream product

• 67-56-1 methanol 
• 29738-09-8 (R)-2-amino-2-phenylpropanoic acid 
• 929030-93-3 (R)-dibenzyl1-(1-oxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate 
• 82944-84-1 N-[(1E)-1-phenylethylidene]-P,P-diphenylphosphinic amide 
• 613-91-2 acetophenone oxime 
• 98-86-2 acetophenone 
• 1092559-83-5 C₁₀H₁₁N₃O₂ 
• 929031-14-1 (-)-N,N'-bis(benzyloxycarbonyl)-2-hydrazino-2-phenylpropionic acid methyl ester 

Downstream Products

• 191422-06-7 (S)-3-Benzyloxycarbonylamino-N-((R)-1-methoxycarbonyl-1-phenyl-ethyl)-succinamic acid 
• 29738-09-8 (R)-2-amino-2-phenylpropanoic acid 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT

Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections

Bifunctional iminophosphorane organocatalysts for enantioselective synthesis: Application to the ketimine nitro-Mannich reaction

The design, synthesis, and development of a new class of modular, strongly basic, and tunable bifunctional Bronsted base/H-bond-donor organocatalysts are reported. These catalysts incorporate a triaryliminophosphorane as the Bronsted basic moiety and are readily synthesized via a last step Staudinger reaction of a chiral organoazide and a triarylphosphine. Their application to the first general enantioselective organocatalytic nitro-Mannich reaction of nitromethane to unactivated ketone-derived imines allows the enantioselective construction of β-nitroamines possessing a fully substituted carbon atom. The reaction is amenable to multigram scale-up, and the products are useful for the synthesis of enantiopure 1,2-diamine and α-amino acid derivatives.

A new type of oxidation-reduction condensation by the combined use of phenyl diphenylphosphinite and oxidant

A new type of oxidation-reduction condensation of alcohols with sulfur, nitrogen, and oxygen nucleophiles by the combined use of phenyl diphenylphosphinite (PhOPPh2) and oxidants such as azides or diethyl azodicarboxylate (DEAD) are described. In these reactions, chiral secondary and tertiary alcohols are converted into the corresponding chiral sulfides, azides, esters and ethers under mild and neutral conditions with almost complete inversion of stereochemical configuration.

The proline-catalyzed asymmetric amination of branched aldehydes

An efficient access to configurationally stable α,β- disubstituted α-amino aldehydes, oxazolidinones, and α-amino acids has been presented. Starting from simple and easily available racemic aldehydes, the α-aminated products were obtained using azodicarboxylates as the nitrogen source in up to 86 % ee and moderate to excellent yield. These products could further be converted both into the corresponding α-amino alcohols and, depending on the residue of the azodicarboxylates and the reaction conditions, into the oxazolidinones. On the other hand, oxidation towards the carboxylic acid and cleavage of the hydrazide bond under mild conditions revealed the free α-alkylated phenylglycine derivative. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Aspartame dipeptide analogues: Effect of number of side-chain methylene group spacers and C(α)-methylation in the second position

Our model of the active site of the sweet taste receptor is shown to be consistent with the aspartame analogues in which the L-Phe2 residue is replaced by L-(αMe)Phg, L-(αMe)Phe or L-(αMe)Hph. The analogues containing either the first or the th