36070-79-8

Basic information

• Product Name: 6-CHLORO-2-PYRAZINECARBOXAMIDE
• Synonyms: 6-CHLORO-2-PYRAZINECARBOXAMIDE;2-Chloro-6-pyrazinecarboxamide;6-Chloropyrazine-2-carboxamide;6-Chloropyrazinecarboxamide;6-chloro-2-pyrazinecarboxamide(SALTDATA: FREE);6-Chloropyrazine-2-carboxylic acid amide;PyrazinecarboxaMide, 6-chloro-
• CAS NO: 36070-79-8
• Molecular Formula: C₅H₄ClN₃O
• Molecular Weight: 157.55776
• Mol File: 36070-79-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 180-182℃
• Boiling Point: 311.7 °C at 760 mmHg
• Flash Point: 142.3 °C
• Appearance: /
• Density: 1.478±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.000556mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 6-CHLORO-2-PYRAZINECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-2-PYRAZINECARBOXAMIDE(36070-79-8)
• EPA Substance Registry System: 6-CHLORO-2-PYRAZINECARBOXAMIDE(36070-79-8)

Safety Data

• Hazardous Substances Data: 36070-79-8(Hazardous Substances Data)

Usage

General Description

6-CHLORO-2-PYRAZINECARBOXAMIDE is a chemical compound with the molecular formula C5H4ClN3O. It is a derivative of pyrazine and is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. 6-CHLORO-2-PYRAZINECARBOXAMIDE is known for its potential as a building block in the development of various drugs and agrochemicals due to its diverse reactivity and functional groups. Additionally, it is also used as an intermediate in the synthesis of pyrazinamide, an antibiotic used to treat tuberculosis. This chemical has shown promising properties and is a significant part of the chemical industry due to its wide range of applications and contributions to drug discovery and agricultural technology.

InChI:InChI=1/C5H4ClN3O/c6-4-2-8-1-3(9-4)5(7)10/h1-2H,(H2,7,10)

Upstream product

• 14508-49-7 2-chloropyrazin 
• 77287-34-4 formamide 
• 6863-74-7 6-chloropyrazine-2-carbonitrile 
• 98-97-5 2-pyrazylcarboxylic acid 
• 148673-71-6 6-chloropyrazine-2-carboxylic acid chloride 
• 768-36-5 2-pyrazinecarboxamide-4-oxide 
• 23688-89-3 6-chloropyrazine-2-carboxylic acid 
• 4774-14-5 2,6-dichloropyrazine 
• 151-50-8 potassium cyanide 

Downstream Products

• 33332-49-9 6-Aminopyrazinecarboxamide 
• 1537902-08-1 6-(2-phenylethylamino)pyrazine-2-carboxamide 
• 1537902-09-2 6-(3-phenylpropylamino)pyrazine-2-carboxamide 

Relevant articles and documents

Alkylamino derivatives of pyrazinamide: Synthesis and antimycobacterial evaluation

A series of pyrazinamide derivatives with alkylamino substitution was designed, synthesized and tested for their ability to inhibit the growth of selected mycobacterial, bacterial and fungal strains. The target structures were prepared from the corresponding 5-chloro (1) or 6-chloropyrazine-2-carboxamide (2) by nucleophilic substitution of chlorine by various non-aromatic amines (alkylamines). To determine the influence of alkyl substitution, corresponding amino derivatives (1a, 2a) and compounds with phenylalkylamino substitution were prepared. Some of the compounds exerted antimycobacterial activity against Mycobacterium tuberculosis H37Rv significantly better than standard pyrazinamide and corresponding starting compounds (1 and 2). Basic structure-activity relationships are presented. Only weak antibacterial and no antifungal activity was detected.

PYRROLIDONES WITH ANTI-HIV ACTIVITY

The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhi

Pyrazine-2-carboxylic acid N-oxides. IV. Reaction of pyrazine-2-carboxamide 4-N-oxide with phosphorus oxycholoride

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