16535-88-9

Basic information

• Product Name: Benzeneacetic acid, 2-acetyl-, methyl ester
• CAS NO: 16535-88-9
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Mol File: 16535-88-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 2-acetyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2-acetyl-, methyl ester(16535-88-9)
• EPA Substance Registry System: Benzeneacetic acid, 2-acetyl-, methyl ester(16535-88-9)

Safety Data

• Hazardous Substances Data: 16535-88-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 36073-90-2 2-(2-acetylphenyl)acetic acid 
• 186581-53-3 diazomethane 
• 105-45-3 acetoacetic acid methyl ester 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 4531-60-6 2-morpholino-2-penten-4-one 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 
• 799804-49-2 (2-trimethylsilanylethynyl-phenyl)-acetic acid methyl ester 
• 66370-75-0 methyl (2-iodophenyl)acetate 
• 637348-19-7 (2-ethynylphenyl)acetic acid methyl ester 
• 1026415-28-0 [2-(1-butoxy-vinyl)-phenyl]-acetic acid methyl ester 

Downstream Products

• 799804-36-7 methyl 2-(2-{2-[(methylsulfonyloxy)oxy]acetyl}phenyl)acetate 
• 29427-70-1 methyl 3-oxo-2,3-dihydro-1H-indene-1-carboxylate 
• 16535-89-0 3-hydroxy-1-methylisoquinoline 
• 363159-41-5 {2-[2-(2-Nitro-phenyl)-acetyl]-phenyl}-acetic acid methyl ester 
• 67-56-1 methanol 
• 36073-90-2 2-(2-acetylphenyl)acetic acid 

Relevant articles and documents

Copper-Catalyzed Formation of α-Alkoxycycloalkenones from N-Tosylhydrazones

The combination of 20 mol % of copper iodide and lithium tert-butoxide triggers the formation of a broad range of substituted, functionalized α-alkoxy 2H-naphthalenones from readily available N-tosylhydrazones. The data suggests that this transformation occurs through cycloaddition of a copper carbenoid with an ester, followed by a Lewis acid-catalyzed [1,2] alkyl shift of the in situ generated alkoxyepoxide intermediate. The combination of 20 mol % of copper iodide and lithium tert-butoxide triggers the formation of a broad range of substituted, functionalized α-alkoxy 2H-naphthalenones from readily available N-tosylhydrazones. The reaction proceeds by the cycloaddition of a copper carbenoid with an ester, and a subsequent Lewis acid-catalyzed [1,2] alkyl shift of the in situ generated alkoxyepoxide intermediate.

Expedient synthesis of 3-hydroxyisoquinolines and 2-hydroxy-1,4- naphthoquinones via one-pot aryne acyl-alkylation/condensation

A convenient method is disclosed for the synthesis of both 3-hydroxyisoquinolines and 2-hydroxy-1,4-naphthoquinones from β-ketoesters using a one-pot aryne acyl-alkylation/condensation procedure. When performed in conjunction with a one-step method for the synthesis of the β-ketoester substrates, this method provides a new route to these polyaromatic structures in only two steps from commercially available carboxylic acid starting materials. The utility of this approach is demonstrated in the synthesis of the atropisomeric P,N-ligand, QUINAP. The Royal Society of Chemistry 2009.

The direct acyl-alkylation of arynes

An efficient and mild acyl-alkylation of arynes is described. The method is used to synthesize medium-sized carbocycles by the ring-expansion of cyclic β-ketoesters. Copyright