36076-19-4Relevant articles and documents
Diastereoselective Amplification of a Mechanically Chiral [2]Catenane
Besnard, Céline,Caprice, Kenji,Cougnon, Fabien B. L.,Frontera, Antonio,Galmés, Bartomeu,Pál, Dávid
supporting information, p. 11957 - 11962 (2021/08/20)
Achiral [2]catenanes composed of rings with inequivalent sides may adopt chiral co-conformations. Their stereochemistry depends on the relative orientation of the interlocked rings and can be controlled by sterics or an external stimulus (e.g., a chemical stimulus). Herein, we have exploited this stereodynamic property to amplify a mechanically chiral (P)-catenane upon binding to (R)-1,1′-binaphthyl 2,2′-disulfonate, with a diastereomeric excess of 85%. The chirality of the [2]catenane was ascertained in the solid state by single crystal X-ray diffraction and in solution by NMR and CD spectroscopies. This study establishes a robust basis for the development of a new synthetic approach to access enantioenriched mechanically chiral [2]catenanes.
INTERMEDIATE AND PROCESS FOR THE PREPARATION OF A SULFONAMIDE DERIVATIVE
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Page/Page column 16, (2013/03/26)
The invention relates to a crystalline form of 2-chloro-N-{2-[3-(2-{[(4'-hydroxybiphenyl-3- yl)methyl]amino}-2-oxoethyl)phenyl]-1,1-dimethylethyl}acetamide, a process for preparing the same and its use in the preparation of the ?2 agonist N-[(4'-hydroxybiphenyl-3- yl)methyl]-2-(3-{2-[((2R)-2-hydroxy-2-{4-hydroxy-3- [(methylsulfonyl)amino]phenyl}ethyl)amino]-2-methylpropyl} phenyl)acetamide which is useful in the treatment of respiratory diseases.
CARBONYLATION OF 1,4-DI(CHLOROMETHYL)BENZENE AND ALLYL CHLORIDE IN METHANOL, CATALYZED BY DICOBALT OCTACARBONYL
Terekhova, M. I.,Kron, T. E.,Petrova, N. E.,Petrov, E. S.
, p. 2101 - 2104 (2007/10/02)
The effects of inorganic base on the yield and selectivity of carbonylation of 1,4-di(chloromethyl)benzene and allyl chloride, catalyzed by dicobalt octacarbonyl, in methanol with carbon monoxide at atmospheric pressure have been examined.The highest yields of products were obtained with K2CO3 and Na2CO3.Addition of MeI results in a considerable increase in yields in the presence of calcium bases, givimg dimethyl 1,4-phenylenediacetate, which in the absence of MeI is formed in appreciable amounts only in the presence of sodium carbonate.