360778-80-9Relevant academic research and scientific papers
Synthetic studies on (+)-naphthyridinomycin: Stereoselective synthesis of the tetracyclic core framework
Mori, Kazuki,Rikimaru, Kentaro,Kan, Toshiyuki,Fukuyama, Tohru
, p. 3095 - 3097 (2007/10/03)
(Chemical Equation Presented) The stereoselective synthesis of the tetracyclic intermediate 21 for (+)-naphthyridinomycin (1) has been accomplished. The convergent synthesis used the Ugi 4CC reaction with the amine derivative 10. The key features of the s
Synthesis of optically active α-arylglycines: Stereoselective Mannich-type reaction with a new chiral template
Tohma,Endo,Kan,Fukuyama
, p. 1179 - 1181 (2007/10/03)
Mannich-type reaction of phenols with iminolactone 4, readily prepared from commercially available phenylglycine, proceeded with high stereoselectivity to give α-arylglycine derivatives. The reaction was also applicable to other electron-rich aromatic compounds and aryl boronic acids. These adducts could be readily converted to the corresponding optically active α-arylglycines.
