361-72-8

Usage

Uses

Used in Pharmaceutical Industry:
3,5-Difluoro-2-nitroaniline is used as a key intermediate in the synthesis of various pharmaceutical products. Its unique structure allows for the creation of new drug molecules with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic chemistry, 3,5-difluoro-2-nitroaniline is employed as a building block for the production of a wide range of organic compounds. Its presence in these compounds can influence their chemical properties and reactivity, making it a valuable component in the synthesis of various molecules.

InChI:InChI=1/C6H4F2N2O2/c7-3-1-4(8)6(10(11)12)5(9)2-3/h1-2H,9H2

Upstream product

• 404-01-3 N-(3,5-difluorophenyl)acetamide 
• 1052686-55-1 2,2,2-trifluoro-N-(3,5-difluoro-2-nitrophenyl)acetamide 
• 361-71-7 3,5-difluoro-2-nitroacetanilide 
• 372-39-4 3,5-difluoroaniline 
• 315-14-0 1,3,5-trifluoro-2-nitrobenzene 

Downstream Products

• 1035388-12-5 5-fluoro-3-morpholino-2-nitroaniline 
• 1052686-56-2 5-fluoro-2-nitro-3-(1H-pyrazol-1-yl)benzenamine 
• 873662-28-3 5-fluoro-3-methoxybenzene-1,2-diamine 
• 2091140-87-1 3-fluoro-5-methoxy-2-nitroaniline 
• 859536-42-8 5-fluoro-3-(2-methoxyphenoxy)-2-nitroaniline 
• 934765-55-6 4-[(3-amino-5-fluoro-4-nitrophenyl)oxy]benzaldehyde 
• 934765-58-9 {3-fluoro-5-[(4-formylphenyl)oxy]-2-nitrophenyl}formamide 

Relevant academic research and scientific papers

Synthesis and Structural Investigation of Some Electron-Rich Nitroaromatics

2,4-Difluoro-, 2,4,6-Trifluoro-, and 2,3,4,6,tetrafluoronitrobenzenes undergo nucleophilic aromatic substitution, once, twice, and three times with a variety of amine substituents with a high degree of regiochemical control to provide a range of electron-

Revisiting the Synthesis of 4,6-Difluorobenzofuroxan: A Study of Its Reactivity and Access to Fluorinated Quinoxaline Oxides

New quinoxaline 1,4-dioxide derivatives have been synthesized from novel fluorinated benzofuroxans such as 4-fluorobenzofuroxan, which is prepared for the first time. Furthermore, the preparation 4,6-difluorobenzofuroxan has been revisited because we were

Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: Intelligent design and evolution through the judicious use of structure-guided design and stucture-activity relationships

The discovery of new antibacterial agents with novel mechanisms of action is necessary to overcome the problem of bacterial resistance that affects all currently used classes of antibiotics. Bacterial DNA gyrase and topoisomerase IV are well-characterized clinically validated targets of the fluoroquinolone antibiotics which exert their antibacterial activity through inhibition of the catalytic subunits. Inhibition of these targets through interaction with their ATP sites has been less clinically successful. The discovery and characterization of a new class of low molecular weight, synthetic inhibitors of gyrase and topoisomerase IV that bind to the ATP sites are presented. The benzimidazole ureas are dual targeting inhibitors of both enzymes and possess potent antibacterial activity against a wide spectrum of relevant pathogens responsible for hospital- and community-acquired infections. The discovery and optimization of this novel class of antibacterials by the use of structure-guided design, modeling, and structure-activity relationships are described. Data are presented for enzyme inhibition, antibacterial activity, and in vivo efficacy by oral and intravenous administration in two rodent infection models.