361393-65-9Relevant academic research and scientific papers
Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H- tetrazol-5-amine P2X7 antagonists
Perez-Medrano, Arturo,Donnelly-Roberts, Diana L.,Florjancic, Alan S.,Nelson, Derek W.,Li, Tongmei,Namovic, Marian T.,Peddi, Sridhar,Faltynek, Connie R.,Jarvis, Michael F.,Carroll, William A.
scheme or table, p. 3297 - 3300 (2011/07/07)
Synthesis and biological evaluation of a novel class of substituted N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine derivatives resulted in the identification of potent P2X7 antagonists. These compounds were assayed for activity at both the
ARYL FLUOROETHYL UREAS ACTING AS ALPHA 2 ADRENERGIC AGENTS
-
Page/Page column 26-27, (2008/12/07)
The invention provides well-defined aryl fluoroethyl ureas that are useful as selective alpha2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of alpha2 adrenergic receptors.
THERAPEUTIC FLUOROETHYLCYANO GUANIDINES
-
Page/Page column 10-11, (2008/12/04)
Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
P2X7 receptor antagonists and methods of use
-
Page/Page column 22, (2010/11/27)
The invention is directed to compounds that are P2X7 antagonist and have the formula (I) or (II) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug or a combination thereof, wherein R1, R2, and R3 /sub
AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE
-
Page/Page column 96, (2010/02/14)
A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R 5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
Imidazole compounds
-
, (2008/06/13)
A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
