361432-76-0Relevant articles and documents
Microbiological synthesis of 17β-hydroxyandrosta-1,4-dien-3-one
Popova,Gabinskaya,Shuvalova,Dovzhenko,Andryushina
, p. 174 - 175 (2001)
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Wenger,R. et al.
, p. 2420 - 2426 (1962)
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Fried et al.
, p. 5764 (1953)
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Ringold et al.
, p. 239 (1956)
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Old yellow enzyme-catalyzed dehydrogenation of saturated ketones
Schittmayer, Matthias,Glieder, Anton,Uhl, Michael K.,Winkler, Andreas,Zach, Simone,Schrittwieser, Joerg H.,Kroutil, Wolfgang,MacHeroux, Peter,Gruber, Karl,Kambourakis, Spiros,Rozzell, J. David,Winkler, Margit
experimental part, p. 268 - 274 (2011/04/22)
Enzymes from extremophiles have always been of great interest for biotechnology because of their ruggedness against various stress factors. We have isolated, cloned, heterologously expressed and characterized a thermostable old yellow enzyme (OYE) from Geobacillus kaustophilus. In addition to the expected 'enone' reduction, GkOYE also catalyzes the reverse reaction, i.e., the desaturation of C-C bonds adjacent to a carbonyl to give the corresponding α,β-unsaturated ketone. The reaction proceeds at the expense of molecular oxygen without the need for a nicotinamide cofactor and represents an environmentally benign alternative to known chemical dehydrogenation methods.
Reduction of steroidal ketones with amine - Boranes
Leontjev,Vasiljeva,Pivnitsky
, p. 703 - 708 (2007/10/03)
Complexes of secondary amines with borane, R2NH·BH 3, surpass sodium borohydride as reducing agents for saturated and unsaturated steroidal 3-, 12-, 17-, and 20-ketones as regards chemo- and regioselectivity and mildness of the reaction conditions. In the case of 12-ketones, stereoselectivity is also improved.