361456-00-0Relevant articles and documents
Cell permeability as a parameter for lead generation in the protein Tyrosine kinase inhibition field
Papageorgiou, Christos,Camenisch, Gian,Borer, Xaver
, p. 1549 - 1552 (2001)
Based on the inverse relationship between polar surface area and cell permeability and capitalizing on the properties of pyrrolopyrimidines 1 as protein tyrosine kinase inhibitors, pyrrolopyridones 2 were designed and synthesized as potential leads for th