361479-94-9

Basic information

• Product Name: 3-Pyridinecarboxylicacid,4-ethyl-2,6-dimethyl-,ethylester(9CI)
• Synonyms: 3-Pyridinecarboxylicacid,4-ethyl-2,6-dimethyl-,ethylester(9CI)
• CAS NO: 361479-94-9
• Molecular Formula: C12H17NO2
• Molecular Weight: 0
• Product Categories: ETHYL
• Mol File: 361479-94-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Pyridinecarboxylicacid,4-ethyl-2,6-dimethyl-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylicacid,4-ethyl-2,6-dimethyl-,ethylester(9CI)(361479-94-9)
• EPA Substance Registry System: 3-Pyridinecarboxylicacid,4-ethyl-2,6-dimethyl-,ethylester(9CI)(361479-94-9)

Safety Data

• Hazardous Substances Data: 361479-94-9(Hazardous Substances Data)

Upstream product

• 1679-36-3 3-hexyn-2-one 
• 626-34-6 ethyl 3-aminobut-2-enoate 
• 141-97-9 ethyl acetoacetate 
• 41867-20-3 ethyl (E)-3-aminobut-2-enoate 
• 626-34-6 ethyl aminocrotonate 

Relevant articles and documents

One-pot multistep Bohlmann-Rahtz heteroannulation reactions: Synthesis of dimethyl sulfomycinamate

(Chemical Equation Presented) The synthesis of dimethyl sulfomycinamate, the acidic methanolysis product of the sulfomycin family of thiopeptide antibiotics, from methyl 2-oxo-4-(trimethylsilyl)but-3-ynoate is achieved in a 2,3,6-trisubstituted pyridine synthesis that proceeds with total regiocontrol in 13 steps by the Bohlmann-Rahtz heteroannulation of a 1-(oxazol-4-yl)enamine or in 12 steps and 9% yield by three-component cyclocondensation with N-[3-oxo-3-(oxazol-4-yl)propanoyl]serine and ammonia in ethanol.

New N-halosuccinimide-mediated reactions for the synthesis of pyridines

5-Bromo-2,6-dialkylpyridine-4-carboxylates are generated in excellent yield by the Michael addition of enaminoesters and ethynyl ketones followed by bromocyclization using N-bromosuccinimide within 1 hour at 0°C. Treatment of the same aminopentadienone intermediates with N-iodosuccinimide facilitates a low temperature cyclodehydration under very mild conditions to give 2,3,6-trisubstituted pyridines with total regiocontrol.

A new one-pot three-component condensation reaction for the synthesis of 2,3,4,6-tetrasubstituted pyridines

The one-pot three-component condensation of a β-ketoester, ammonia and an alkynone in the presence of a Bronsted or Lewis acid or Amberlyst 15 ion exchange resin provided 2,3,6-trisubstituted or 2,3,4,6-tetrasubstituted pyridines directly in good yield and with total regiocontrol.