36149-75-4Relevant articles and documents
Copper powder-catalyzed chelation-assisted cascade reaction of: O -chloroarylacetic acids with amines under solvent- and ligand-free conditions: Synthesis of oxindoles
Li, Jiang-Sheng,Chen, Guo-Qin,Yang, Qian,Li, Zhi-Wei,Liu, Ci-Zhi,Huang, Peng-Mian
, p. 45227 - 45231 (2017/10/13)
An efficient method to construct oxindole scaffolds from o-chloroarylacetic acids/esters with amines has been explored. This cascade protocol involves the in situ generation of o-aminoarylacetic acid derivatives by the copper powder catalyzed and weak O-chelation assisted Ullmann amination of unactivated C-Cl bonds under air, and solvent-/ligand-free conditions followed by annulative N-acylation.
Rearrangements of N-Nitrenes: a 15N- Labelling Study of the Mechanism of the Conversion of 1-Aminoindol-2-one to Cinnolin-3(2H)-one
Williams, Michael T.
, p. 1185 - 1194 (2007/10/02)
The oxidation of 1-aminoindol-2-one to cinnolin-3(2H)-one is shown by 15N labelling to proceed by migration of acyl rather than the aryl group to the exocyclic nitrogen.Two cinnolin-3(2H)-ones were found to extrude carbon monoxide upon flash vacuum pyrolysis giving indazoles.