361569-01-9

Upstream product

• 350228-89-6 (+)-tert-butyl (R)-4-benzyl-3-[(S)-1-(pyrrolidin-1-yl)ethyl]piperazine-1-carboxylate 
• 361568-86-7 tert-butyl (R)-3-[(S)-1-(pyrrolidin-1-yl)ethyl]piperazine-1-carboxylate 
• 350228-88-5 (+)-tert-butyl (R)-3-acetyl-4-benzylpiperazine-1-carboxylate 
• 249611-19-6 (3R)-(-)-tert-Butyl 4-benzyl-3-[(1R)-1-hydroxyethyl]piperazine-1-carboxylate 
• 5807-30-7 3,4-dichlorophenyl acetic acid 
• 350228-91-0 (+)-tert-butyl (R)-4-[2-(3,4-dichlorophenyl)acetyl]-3-[(S)-1-(pyrrolidin-1-yl)ethyl]piperazine-1-carboxylate 

Relevant academic research and scientific papers

Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)-3-(pyrrolidin-1-ylmethyl) piperazine-1-carboxylate (GR-89,696) as highly potent κ-receptor agonists: Stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functional

Analogues of the κ-receptor agonist methyl (R)-4-(3,4-dichlorophenylacetyl)-3-(pyrrolidin-1-ylmethyl) piperazine-1-carboxylate (GR-89,696, 6) bearing an additional methyl substituent in the side chain are synthesized and evaluated for their κ-receptor aff

Synthesis and stereoselective κ-receptor binding of methylated analogues of GR-89.696

Stereoselective synthesis of all four stereoisomers of methylated analogues 8 of the κ-receptor agonist GR-89.696 is presented. Starting with orthogonally protected piperazine derivatives (R,R)-4 and (S,S)-4, the reaction sequence involves oxidation, redu