3617-11-6

Usage

Heterocyclic aromatic organic compound

1H-Imidazole, 2,2'-(1,4-phenylene)bis[4,5-dihydrois a compound that contains a heterocyclic ring, which is a ring containing at least one atom that is not carbon, such as nitrogen in this case. This property gives it unique chemical and physical properties.

Derivative of imidazole

1H-Imidazole, 2,2'-(1,4-phenylene)bis[4,5-dihydro- is derived from imidazole, which is a five-membered ring structure containing three carbon atoms and two nitrogen atoms. The presence of this imidazole ring in the compound contributes to its chemical reactivity and potential applications.

Phenylene group

The compound contains a phenylene group, which is a benzene ring connected to two adjacent nitrogen atoms. This group is responsible for the compound's utility in the synthesis of certain drugs and biologically active molecules.

Use in pharmaceutical applications

1H-Imidazole, 2,2'-(1,4-phenylene)bis[4,5-dihydrois used in the pharmaceutical industry for the synthesis of various drugs and biologically active molecules due to its unique structure and reactivity.

Use in industrial applications

The compound is also used in industrial processes, such as the production of dyes and pigments, due to its chemical properties and structure.

Versatility

The combination of its structure, properties, and potential applications make 1H-Imidazole, 2,2'-(1,4-phenylene)bis[4,5-dihydroa versatile and important chemical in various fields.

Upstream product

• 156732-82-0 2,4-bis<(4-carbamoyl)phenyl>-1,3,5-triazine 
• 156732-93-3 2,4-bis(4-bromophenyl)-1,3,5-triazine 
• 59855-11-7 4-carbamoylbenzamidine hydrochloride 
• 100-21-0 terephthalic acid 
• 333-18-6 1,2-diaminoethane dihydrochloride 
• 107-15-3 ethylenediamine 
• 156732-81-9 2,4-bis(4-cyanophenyl)-1,3,5-triazine 
• 46321-75-9 Dimethyl benzene-1,4-bis 
• 623-26-7 terephthalonitrile 

Downstream Products

• 47578-88-1 1,4-bis(1-phenyl-4,5-dihydro-1H-imidazol-2-yl)benzene 
• 13752-21-1 1,4-bis(imidazolyl)benzene 

Relevant academic research and scientific papers

Non-chelating p-phenylidene-linked bis-imidazoline analogs of known influenza virus endonuclease inhibitors: Synthesis and anti-influenza activity

A novel chemotype topologically similar to known influenza virus PA endonuclease inhibitors has been designed. It was aimed to reproduce the extended topology of the known metal-chelating ligands with a p-phenylidene-linked bis-imidazoline scaffold. It wa

Cu(II) immobilized on Fe3O4@Agarose nanomagnetic catalyst functionalized with ethanolamine phosphate–salicylaldehyde schiff base: A magnetically reusable nanocatalyst for preparation of 2-substituted imidazolines, oxazolines, and thiazolines

Herein we synthesized Cu(II) immobilized on Fe 3 O 4 @Agarose functionalized with ethanolamine phosphate–salicylaldehyde Schiff base (Fe 3 O 4 @Agarose/SAEPH 2 /Cu(II)) as a new and cost-effective nanomagnetic catalyst. The nanomagnetic catalyst was characterized by FT- IR, XRD, VSM, SEM- EDX, TEM, TGA, and ICP techniques and it was found that the particles were about 9–25 nm in size and spherical with entrapment of the Fe 3 O 4 particles in the hollow pore structure of the agarose. The prepared nanomagnetic catalyst showed excellent activity for preparation of 2-substituted imidazolines, oxazolines, and thiazolines. The catalyst is easy to prepare and exhibits higher catalytic activity than some commercially available copper sources. More importantly, this nanomagnetic catalyst can be easily recovered by using a permanent magnet and reused for at least seven cycles without significant deactivation.

Copper-catalyzed synthesis of 2-imidazolines and their N-hydroxyethyl derivatives under various conditions

A rapid and efficient method for the synthesis of 2-imidazolines and their N-hydroxyethyl derivatives from the reaction of aromatic nitriles with ethylenediamine (EDA) or N-(2-aminoethyl)ethanolamine (AEEA) using cupric indole-3-acetate (Cu(II)-(IAA)2) as a reusable catalyst under reflux and microwave conditions is reported. And seven new N-hydroxyethyl-imidazolines were reported for the first time.

Efficient and one-pot catalytic synthesis of 2-imidazolines and bis-imidazolines with p-toluenesulfonic acid under solvent free conditions

A practical, efficient, and inexpensive method for the synthesis of 2-imidazoline from the reaction of nitriles with ethylenediamine or 1,2-propanediamine using p-toluenesulfonic acid or pyridinium p-toluenesulfonate under reflux conditions is reported. This catalyst can be successfully applied for the chemoselective conversion of dicyanobenzenes to corresponding mono- and bis-imidazolines. The applications of these catalysts are feasible because of easy preparation, easy handling, stability, inexpensive, good activity, and eco-friendly.

Efficient catalytic synthesis of 2-imidazolines and bis-imidazolines with silica supported tungstosilicic acid

A rapid and efficient preparation of 2-imidazolines and bis-imidazolines by the reaction of ethylenediamine or 1,2-propanediamine with nitriles in the presence of catalytic amounts of tungstosilicic acid supported on SiO 2 under reflux condition, is reported. The advantages of this procedure are moderate reaction times, good to high yields and the ability to carry out the large scale reactions. ARKAT USA, Inc.

Rapid and efficient synthesis of imidazolines and bisimidazolines under microwave and ultrasonic irradiation

Small assemblies of 2-imidazolines and bisimidazolines from appropriate nitriles and ethylenediamine with catalytic amounts of P2S 5 employing a microwave assisted protocol were prepared. Sonication of this system also led to successful synthesis of 2-imidazolines and bisimidazolines. Another advantage of these systems is the ability to carry out large scale reactions. Springer-Verlag 2007.

Cucurbit[7]uril host-guest complexes with cationic bis(4,5-dihydro-1H- imidazol-2-yl) guests in aqueous solution

The host-guest interactions between cucurbit[7]uril and a series of novel cationic bis(4,5-dihydro-1H-imidazol-2-yl)arene and 1-(4,5-dihydro-1H-imidazol- 2-yl)- and 1,3-bis(4,5-dihydro-1H-imidazol-2-yl)-adamantane guests have been investigated in aqueous

Rapid and efficient synthesis of 2-imidazolines and bis-imidazolines under ultrasonic irradiation

Rapid and efficient preparation of 2-imidazolines and bis-imidazolines by reaction of ethylenediamine with nitriles in the presence of catalytic amounts of sulfur under ultrasonic irradiation is reported. The advantages of this system are short reaction times, high yields and the ability to carry out large scale reactions.

Synthesis of dicationic diaryltriazines nucleic acid binding agents

The synthesis of 2,4-bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]- 1,3,5-triazine 6a and 2,4-bis[4-(1,4,5,6-tetrahydropyrimidin-2-yl)phenyl]-1,3,5-triazine 6b in 3 steps from either 4-bromobenzamidine or 4-(carbamoyl)benzamidine is reported. The synthesis