333-18-6

Basic information

• Product Name: Ethylenediamine dihydrochloride
• Synonyms: ETHYLENEDIAMMONIUM DICHLORIDE FOR SYNTHE;EthylenediaMine dihydrochlorid;1,2-EthanediaMine,hydrochloride (1:2);1,2-Ethanediamine, hydrochloride;Ethylenediamine dihydrochloride Vetec(TM) reagent grade, 98%;Ethylenediammonium dichloride for synthesis;Ethylenediaminehydrochloride;ethylenediammoniumchloride
• CAS NO: 333-18-6
• Molecular Formula: C₂H₁₀N₂*2Cl
• Molecular Weight: 133.02
• EINECS: 206-369-6
• Mol File: 333-18-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: >300 °C(lit.)
• Boiling Point: 119.7 °C at 760 mmHg
• Flash Point: 33.9 °C
• Appearance: White to off-white/Crystalline Powder
• Density: 1.159g/cm3
• Storage Temp.: Store below +30°C.
• Solubility: water: soluble100mg/mL, clear, colorless to very faintly yellow
• Water Solubility: 300 g/L (20 ºC)
• Sensitive: Hygroscopic
• Stability: Stable. Incompatible with strong oxidizing agents.
• BRN: 3665235
• CAS DataBase Reference: Ethylenediamine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Ethylenediamine dihydrochloride(333-18-6)
• EPA Substance Registry System: Ethylenediamine dihydrochloride(333-18-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-42/43
• Safety Statements: 22-26-36/37-45
• WGK Germany: 2
• RTECS: KV3850000
• TSCA: Yes
• Hazardous Substances Data: 333-18-6(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

Uses

Different sources of media describe the Uses of 333-18-6 differently. You can refer to the following data:
1. Ethylenediamine dihydrochloride is used as stabilizer in steroid creams and rubber latex; inhibitor in antifreeze solutions and cooling fluids; in floor-polish remover; in nystatin cream and aminophylline; epoxy-curing agent; accelerator in color development baths in photography; in veterinary preparations; in electroplating and electrophoretic gels, dyes, fungicides, insecticides, synthetic waxes, textile lubricants, and eye and nose drops; solvent for casein, albumin, shellac.
2. Ethylenediamine dihydrochloride was used in modified ethylenediamine condensation method for fluorimetric determination of catecholamines. It was used to investigate the luminescence properties of complexes of EuIII and TbIII with ethylenediamine. It was used in the synthesis of 1,3,5-tris(4,5-dihydro-1H-imidazol-2-yl)benzene3
3. Ethylenediamine dihydrochloride was used in modified ethylenediamine condensation method for fluorimetric determination of catecholamines. It was used to investigate the luminescence properties of complexes of EuIII and TbIII with ethylenediamine. It was used in the synthesis of 1,3,5-tris(4,5-dihydro-1H-imidazol-2-yl)benzene.

Definition

ChEBI: A hydrochloride that is the dihydrochloride of ethylenediamine.

Safety Profile

Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Purification Methods

Crystallise the salt from H2O or H2O/EtOH. Wash the crystals with EtOH and dry them in vacuo. It sublimes on heating. [Beilstein 4 IV 1168.]

InChI:InChI=1/C4H6N2O2/c1-2-8-4(7)3-6-5/h3H,2H2,1H3

Upstream product

• 15165-88-5 1,2-diaminoethane-bis-borane 
• 7732-18-5 water 
• 107-15-3 ethylenediamine 
• 65276-01-9 2-(1,3-dibenzoylimidazolidin-2-yl)imidazole hydrochloride 
• 607-26-1 N,N'-ethylenediphthalimide 
• 67-56-1 methanol 
• 709038-77-7 ethylenediammonium galactarate 
• 7647-01-0 hydrogenchloride 
• 120-93-4 imidazolidone 
• 543-20-4 succinoyl dichloride 
• 71-43-2 benzene 
• 7782-50-5 chlorine 
• 64-19-7 acetic acid 
• 150-61-8 N,N'-diphenylethylenediamine 

Downstream Products

• 10443-62-6 2-pentadecyl-4,5-dihydro-1H-imidazole 
• 288-39-1 1,2,5-thiadiazole 
• 876954-29-9 (3-cyanomethyl-2-phenyl-imidazolidin-1-yl)-acetonitrile 
• 87196-85-8 [As(C₆H₅)4]⁽¹⁺⁾ tetrazidoethylenediaminecobaltate(III) 
• 4403-78-5 ditosylethylenediamine 
• 81001-99-2 N,N'-ethylenebis(1-phenyl-1,3-propanedione 3-imine) 
• 32746-33-1 N.N'-Ethylen-bis-<1-amino-cyclohexyl-carbonitril-(1)> 
• 44956-51-6 1,1'-(ethane-1,2-diyl)diguanidine 
• 105-28-2 2-heptadecyl-2-imidazoline 
• 4772-67-2 [(2-{[(cyano)(phenyl)methyl]amino}ethyl)amino](phenyl)acetonitrile 
• 18299-54-2 ethylenediamine hydrochloride 
• 607-26-1 N,N'-ethylenediphthalimide 
• 10443-61-5 2-undecyl-2-imidazoline 
• 217-68-5 dibenzo[f,h]quinoxaline 

Relevant articles and documents

Identifying the roles of amino acids, alcohols and 1,2-diamines as mediators in coupling of haloarenes to arenes

Coupling of haloarenes to arenes has been facilitated by a diverse range of organic additives in the presence of KOtBu or NaOtBu since the first report in 2008. Very recently, we showed that the reactivity of some of these additives (e.g., compounds 6 and 7) could be explained by the formation of organic electron donors in situ, but the role of other additives was not addressed. The simplest of these, alcohols, including 1,2-diols, 1,2-diamines, and amino acids are the most intriguing, and we now report experiments that support their roles as precursors of organic electron donors, underlining the importance of this mode of initiation in these coupling reactions.

Hydrolysis of cyclic ureas under microwave irradiation: Synthesis and characterization of 7,8-diaminopelargonic acid

A simple and efficient method for the synthesis of 7,8-diaminopelargonic acid, a key intermediate in the biotin biosynthesis pathway, is reported. The d-desthiobiotin powder was dissolved in concentrated hydrochloric acid, and the solution was exposed to microwave radiation of 2.45 GHz for varying lengths of time ranging from 60 s to 2 min. The product thus obtained was characterized by spectroscopic techniques and confirmed through bioassay. Further, the protocol was extended to the synthesis of several diamines from their corresponding cyclic ureas. The results show that the method is generally applicable and not only accelerates the hydrolysis reaction but also offers excellent yields. Copyright Taylor & Francis Group, LLC.