1-(6-(4-Chlorophenyl)-2-methylpyridin-3-yl)ethan-1-one

Base Information

• Chemical Name: 1-(6-(4-Chlorophenyl)-2-methylpyridin-3-yl)ethan-1-one
• CAS No.: 36175-15-2
• Molecular Formula: C14H12ClNO
• Molecular Weight: 245.70400
• Mol file: 36175-15-2.mol

Synonyms:1-(6-(4-Chlorophenyl)-2-methylpyridin-3-yl)ethan-1-one;1-[6-(4-chlorophenyl)-2-methylpyridine-3-yl]ethanone;1-(2-methyl-6-(p-chlorophenyl)pyridin-3-yl)ethanone;1-[6-(4-Chloro-phenyl)-2-methyl-pyridin-3-yl]-ethanone;

Chemical Property of 1-(6-(4-Chlorophenyl)-2-methylpyridin-3-yl)ethan-1-one

Chemical Property:

• PSA: 29.96000
• LogP: 3.91300
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(6-(4-Chlorophenyl)-2-methylpyridin-3-yl)ethanone AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(6-(4-Chlorophenyl)-2-methylpyridin-3-yl)ethan-1-one

There total 3 articles about 1-(6-(4-Chlorophenyl)-2-methylpyridin-3-yl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one (67382-35-8,28587-05-5) + acetylacetone (123-54-6,81235-32-7) → 1-(6-(4-chlorophenyl)-2-methylpyridin-3-yl)ethan-1-one (36175-15-2)

Guidance literature:

With ammonium acetate; K5; at 115 ℃; for 0.75h;

DOI:10.1016/j.tet.2007.10.014

Reference yield: 65.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-(4-chlorophenyl)ethanone O-acetyl oxime (184849-67-0) + acetylacetone (123-54-6,81235-32-7) → 1-(6-(4-chlorophenyl)-2-methylpyridin-3-yl)ethan-1-one (36175-15-2)

Guidance literature:

With lithium carbonate; copper(I) bromide; In dimethyl sulfoxide; at 120 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.joc.5b01621

Reference yield:

3-dimethylamino-1(4-chloro-phenyl)-2-propen-1-one (28587-05-5) + acetylacetone (123-54-6,81235-32-7) → 1-(6-(4-chlorophenyl)-2-methylpyridin-3-yl)ethan-1-one (36175-15-2)

Guidance literature:

With ammonium acetate; In acetic acid; microwave irradiation;

DOI:10.1515/HC.2008.14.1-2.55

upstream raw materials:

(2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one

acetylacetone

3-dimethylamino-1(4-chloro-phenyl)-2-propen-1-one

formaldehyd

Downstream raw materials:

C₁₄H₁₁BrClNO

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