184849-67-0

Basic information

• Product Name: Ethanone, 1-(4-chlorophenyl)-, O-acetyloxime
• CAS NO: 184849-67-0
• Molecular Formula: C10H10ClNO2
• Molecular Weight: 211.648
• Mol File: 184849-67-0.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(4-chlorophenyl)-, O-acetyloxime(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-chlorophenyl)-, O-acetyloxime(184849-67-0)
• EPA Substance Registry System: Ethanone, 1-(4-chlorophenyl)-, O-acetyloxime(184849-67-0)

Safety Data

• Hazardous Substances Data: 184849-67-0(Hazardous Substances Data)

Upstream product

• 1956-39-4 4-chloroacetophenone oxime 
• 75-36-5 acetyl chloride 
• 99-91-2 para-chloroacetophenone 
• 108-24-7 acetic anhydride 

Downstream Products

• 72666-43-4 2,6-bis(4-chlorophenyl)-4-phenylpyridine 
• 50553-98-5 2,6‐bis(4‐methoxyphenyl)‐4‐phenylpyridine 
• 72666-44-5 2-(4-Chloro-phenyl)-6-(4-methoxy-phenyl)-4-phenyl-pyridine 
• 61820-94-8 1-(4-chlorophenyl)-2-tosylethanone 
• 33064-19-6 3-(4-chlorophenyl)-1-phenyl-1H-pyrazole 
• 36175-15-2 1-(6-(4-chlorophenyl)-2-methylpyridin-3-yl)ethan-1-one 
• 1402452-24-7 6-chloro-1-methyl-3-phenylisoquinoline 
• 1619224-95-1 6-chloro-3-(4-chlorophenyl)-1-methylisoquinoline 
• 458541-37-2 4-(4-chlorophenyl)-pyrimidine 
• 24698-70-2 2-(4-chlorophenyl)quinoline 
• 27993-56-2 1-(4-chlorophenyl)-2-hydroxyethanone 

Relevant articles and documents

Copper-Catalyzed Annulation of Oxime Acetates with α-Amino Acid Ester Derivatives: Synthesis of 3-Sulfonamido/Imino 4-Pyrrolin-2-ones

A copper-catalyzed annulation of oxime acetates and α-amino acid ester derivatives for the easy preparation of 4-pyrrolin-2-ones bearing a 3-amino group has been developed. This process features the oxidation of amines with oxime esters as the internal oxidant to produce the active 1,3-dinucleophilic and 1,2-dielectrophilic species concurrently. The subsequent nucleophilic cyclization realizes the efficient construction of 4-pyrrolin-2-one derivatives.

CuCl2-catalyzed N[sbnd]O bond cleavage of oxime esters: Approach to imidazoheterocycles and furo[3,2-c]chromenyl fused imidazoles

An articulate approach to a diverse set of imidazoheterocycles in good to high yields via a copper-catalyzed aza-annulation of several oxime esters with a group of 2-amino-azaarenes was developed. The above cyclization reaction probably proceeds via a single electron transfer process which embodies a new technique for creating two new C[sbnd]N bonds for imidazole ring synthesis. Gratifyingly, the implementation of this chemistry could be further stretched to the synthesis of a novel class of fused imidazoles bearing a furo[3,2-c]chromene moiety via a sequential C[sbnd]N bond formation, followed by C(sp2)-H functionalization/5-endo-dig-oxacyclization (C[sbnd]C and C[sbnd]O bonds) of in situ produced fused imidazoles with cyclic enynones in the presence of copper(II) as a π-electrophilic Lewis acid catalyst.

Rhodium(III)-Catalyzed Annulation of Acetophenone O-Acetyl Oximes with Allenoates through Arene C-H Activation: An Access to Isoquinolines

Rhodium(III)-catalyzed annulation of acetophenone O-acetyl oximes with allenoates was achieved, affording isoquinolines in good to excellent yields with high regioselectivities under redox-neutral conditions. Allenoates acted as the C2 synthons in the annulation reaction. The present synthetic methodology features good functional group tolerance and avoids metal salts as the external oxidants. The proposed mechanism suggests that the reaction proceeds through arene C-H activation, allene insertion, and C-N coupling.