3618-37-9Relevant articles and documents
Stetter,Kuhlmann
, p. 29 (1979)
Bifunctional ligands for Pd-catalyzed selective alkoxycarbonylation of alkynes
Qi, Huimin,Huang, Zijun,Wang, Menglan,Yang, Peiju,Du, Chen-Xia,Chen, Shu-Wei,Li, Yuehui
, p. 63 - 68 (2018/05/04)
Catalytic carbonylations of alkynes represent straightforward and atom-economic synthesis of α,β-unsaturated carbonyl compounds. One of the issues associated with the currently known catalytic systems is insufficient efficiency. In this context, Pd/ligand-catalyzed regioselective and efficient alkoxycarbonylation of terminal alkynes is desirable for the synthesis of α,β-unsaturated esters. Herein, we present the use of a newly designed bifunctional ligand for efficient Pd-catalyzed alkoxycarbonylation of alkynes. Both aliphatic and aromatic alkynes were smoothly transformed to the branched desired products with high selectivity (28 examples, 45–96% yields, 95.0–99.9% selectivity).
Design, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors
Yin,Jia,Zhao,Xu,Tang,Wang
, p. 695 - 703 (2011/07/29)
A new series of N-formylhydroxylamines 11a-i have been synthesized through a multi-step protocol starting from diethyl malonate. These compounds have been structurally characterized by IR, 1H NMR and HRMS. All the synthesized compounds 11a-i have been screened for antibacterial activities. All the compounds are found to exhibit potent in vitro inhibitory activity against Staphylococcus aureus and relatively weak antibacterial activity against Klebsiella pneumoniae.
