3619-20-3Relevant academic research and scientific papers
Synthesis and Antiviral Evaluation of New N-acylhydrazones Containing Glycine Residue
Tian, Baohe,He, Meizi,Tan, Zhiwu,Tang, Shixing,Hewlett, Indira,Chen, Shuguang,Jin, Yinxue,Yang, Ming
experimental part, p. 189 - 198 (2012/02/01)
N-acylhydrazones containing glycine residue 3a-j and 8a-h were synthesized as HIV-1 capsid protein assembly inhibitors. The structures of the novel N-acylhydrazone derivatives were characterized using different spectroscopic methods. Antiviral activity de
Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein
Tian, Baohe,He, Meizi,Tang, Shixing,Hewlett, Indira,Tan, Zhiwu,Li, Jiebo,Jin, Yinxue,Yang, Ming
scheme or table, p. 2162 - 2167 (2009/12/25)
HIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC50 values of 0.21 and 0.17 μΜ, respectively.
