3623-02-7

Basic information

• Product Name: 4-(2-Fluorophenoxy)piperidine
• Synonyms: 4-(2-FLUORO-PHENOXY)-PIPERIDINE;CHEMBRDG-BB 4004480;4-(2-fluorophenoxy)piperidine(SALTDATA: HCl);Piperidine, 4-(2-fluorophenoxy)-
• CAS NO: 3623-02-7
• Molecular Formula: C₁₁H₁₄FNO
• Molecular Weight: 195.23
• Mol File: 3623-02-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 287.9 °C at 760 mmHg
• Flash Point: 127.9 °C
• Appearance: /
• Density: 1.108 g/cm³
• Vapor Pressure: 0.00241mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(2-Fluorophenoxy)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Fluorophenoxy)piperidine(3623-02-7)
• EPA Substance Registry System: 4-(2-Fluorophenoxy)piperidine(3623-02-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3623-02-7(Hazardous Substances Data)

Usage

General Description

4-(2-Fluorophenoxy)piperidine is a chemical compound that consists of a piperidine ring with a fluorophenoxy group attached at the 4-position. It is a substituted piperidine derivative that is commonly used in medicinal chemistry as a building block for the synthesis of various pharmaceutical drugs. The compound has the potential to exhibit biological activity due to its structural and functional properties. However, further research and studies are needed to fully understand its pharmacological effects and potential uses in drug development.

InChI:InChI=1/C11H14FNO/c12-10-3-1-2-4-11(10)14-9-5-7-13-8-6-9/h1-4,9,13H,5-8H2

Upstream product

• 944808-08-6 tert-butyl 4-(2-fluorophenoxy)piperidine-1-carboxylate 
• 367-12-4 2-fluorophenol 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Relevant articles and documents

Identification of a new series of benzothiazinone derivatives with excellent antitubercular activity and improved pharmacokinetic profiles

Nitrobenzothiazinone (BTZ) is a promising scaffold with potent activity against M. tuberculosis by inhibiting decaprenylphosphoryl-beta-d-ribose 2′-oxidase (DprE1). But unfavorable durability poses a challenge to further development of this class of agents. Herein, a series of BTZs bearing a variety of different substituents at the C-2 position were designed and synthesized. Compounds were screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Ra and were profiled for metabolic stability, plasma protein-binding capacity and pharmacokinetics in vivo. In general, these new BTZs containing N-piperazine, N-piperidine or N-piperidone moiety have excellent antitubercular activity and low cytotoxicity. Several of the compounds showed improved microsomal stability and lower plasma protein-binding, opening a new direction for further lead optimization. And we obtained compound 3o, which maintained good anti-tuberculosis activity (MIC = 8 nM) and presented better in vitro ADME/T and in vivo pharmacokinetic profiles than reported BTZ compound PBTZ169, which may serve as a candidate for the treatment of tuberculosis.

DERIVATIVES OF TRIAZINES AND URACILS, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPEUTICS

The present invention relates to derivatives of general formula I wherein : - W represents nitrogen, - R1 represents: ? a hydrogen or a linear or branched C1-C5 alkyl radical or, ? a C1-C3 alkyl radical substituted with groups such as trifluoromethyl, nitrile, hydroxy, C1-C3 alcoxy, C3-C6 alkoxyalkoxy, indolyl, thiophenyl, oxothiophenyl, C1-C3 N-alkylcarbamoyl groups or, ? a phenyl or pyridyl or naphthyl, or thiophenyl group optionally substituted with one or more groups such as halogen atoms, nitro, nitrile, trifluoromethyl, vinyl, methylsulfanyl, linear branched C1-C4 alkyl, linear or branched C1-C3 alkoxy groups, ? a C6 2-oxocycloalkyl radical - R2 represents a methyl or heptyl, - m, n are equal to 1, - V represents CH2, - X-Y represents -N- (C=O) -, -CH-O-, - Z represents a phenyl group substituted with one or more trifluoromethyl groups, halogen atoms or linear C1-C4 alkyl groups.