36236-72-3Relevant articles and documents
Synthesis of 1,3-dioxolanes from substituted benzaldehydes of the vanillin series
Dikusar, E. A.,Potkin, V. I.,Zvereva, T. D.,Zhukovskaya, N. A.,Zubenko, Yu. S.,Kletskov, A. V.,Zolotar, R. M.,Chepik, O. P.
, p. 1537 - 1539,3 (2020/09/16)
Abstract-Condensation of substituted benzaldehydes of the vanillin series with propane-1,2-diol and 3- chloropropane-1,2-diol in boiling benzene in the presence of FIBAN K-1 sulfonated cation exchanger as catalyst gave the corresponding substituted 1,3-di
1,3-Dioxolane-based ligands as a novel class of α1-adrenoceptor antagonists
Brasili, Livio,Sorbi, Claudia,Franchini, Silvia,Manicardi, Massimo,Angeli, Piero,Marucci, Gabriella,Leonardi, Amedeo,Poggesi, Elena
, p. 1504 - 1511 (2007/10/03)
1,3-Dioxolane-based compounds (2-14) were synthesized, and the pharmacological profiles at α1-adrenoceptor subtypes were assessed by functional experiments in isolated rat vas deferens (α1A), spleen (α1B), and aorta (α1D). Compound 9, with a pA2 of 7.53, 7.36, and 8.65 at α1A, α1B, and α1D, respectively, is the most potent antagonist of the series, while compound 10 with a pA2 of 8.37 at α1D subtype and selectivity ratios of 162 (α1D/α1A) and 324 (α1D/α1B) is the most selective. Binding assays in CHO cell membranes expressing human cloned α1-adrenoceptor subtypes confirm the pharmacological profiles derived from functional experiments, although the selectivity values are somewhat lower. Therefore, it is concluded that 1,3-dioxolane-based ligands are a new class of α1-adrenoceptor antagonists.
TETRAFLUOROBORIC ACID - A NEW CATALYST FOR THE SYNTHESIS OF 1,3-DIOXOLANES. PREPARATION OF HYDROXYACETONE
Gevorkyan, A. A.,Kazaryan, P. I.,Avakyan, O. V.,Vardanyan, R. A.
, p. 27 - 30 (2007/10/02)
It is established that tetrafluoroboric acid (HBF4) is an effective catalyst for halogen substitution reactions of oxiranes (epichlorohydrin and 1-bromo-3-methyl-2,3-epoxybutane) with aldehydes and ketones, forming 1,3-dioxolanes in high yield.
