362595-04-8

Basic information

• Product Name: 4-(1-benzyl-4,5-diphenyl-1H-imidazol-2-yl)phenol
• Synonyms: 4-(1-benzyl-4,5-diphenyl-1H-imidazol-2-yl)phenol
• CAS NO: 362595-04-8
• Molecular Formula: C28H22N2O
• Molecular Weight: 402.48708
• Mol File: 362595-04-8.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(1-benzyl-4,5-diphenyl-1H-imidazol-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-benzyl-4,5-diphenyl-1H-imidazol-2-yl)phenol(362595-04-8)
• EPA Substance Registry System: 4-(1-benzyl-4,5-diphenyl-1H-imidazol-2-yl)phenol(362595-04-8)

Safety Data

• Hazardous Substances Data: 362595-04-8(Hazardous Substances Data)

Upstream product

• 1752-94-9 4-(4,5-diphenyl-1H-imidazol-2-yl)phenol 
• 100-44-7 benzyl chloride 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 100-46-9 benzylamine 
• 134-81-6 benzil 
• 767-00-0 4-cyanophenol 

Relevant articles and documents

Ag–TiO2 nanocomposite-catalyzed one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles: a green and benign approach

Ag–TiO2 nanocomposite as an efficient catalyst was synthesized and characterized by AFM analysis. This nanocomposite acts as a heterogeneous and recyclable catalyst for the room temperature synthesis of 1,2,4,5-tetrasubstituted imidazoles from aldehydes, benzil, ammonium acetate and several anilines or aliphatic amines via one-pot four-component condensation reaction in H2O as a green solvent. Ag–TiO2 nanocomposite was simply recovered by filtration and was reused up to three times.

An Efficient Synthesis of Substituted Imidazoles Catalyzed by 3-N-Morpholinopropanesulfonic Acid (MOPS) under Ultrasound Irradiation

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In vitro evaluation of arylsubstituted imidazoles derivatives as antiprotozoal agents and docking studies on sterol 14α-demethylase (CYP51) from Trypanosoma cruzi, Leishmania infantum, and Trypanosoma brucei

There is an urgent need to discover and develop new drugs to combat parasitic diseases as Chagas disease (Trypanosoma cruzi), sleeping sickness (Trypanosoma brucei), and leishmaniasis (Leishmania ssp.). These diseases are considered among the 13 most unattended diseases worldwide according to the WHO. In the present work, the synthesis of 14 arylsubstituted imidazoles and its molecular docking onto sterol 14α-demethylase (CYP51) was executed. In addition, the compounds, antiprotozoal activity against T. brucei, T. cruzi, Trypanosoma brucei rhodesiense, and Leishmania infantum was evaluated. In vitro antiparasitic results of the arylsubstituted imidazoles against T. brucei, T. cruzi, T.b. rhodesiense, and L. infantum indicated that all samples from arylsubstituted imidazole compounds presented interesting antiparasitic activity to various extent. The ligands 5a, 5c, 5e, 5f, 5g, 5i, and 5j exhibited strong activity against T. brucei, T. cruzi, T.b. rhodesiense, and L. infantum with IC50 values ranging from 0.86 to 10.23?μM. Most samples were cytotoxic against MRC-5 cell lines (1.12 50 2, SO3H, and OH groups interacts with the Fe2+ ion of the Heme group.