36272-52-3

Upstream product

• 1558-17-4 4,6-dimethylpyrimidine 
• 100-52-7 benzaldehyde 
• 14161-42-3 4,6-dimethylpyrimidine 1-oxide 

Downstream Products

• 78213-69-1 pyrimidine-4,6-dicarboxaldehyde 

Relevant academic research and scientific papers

Shedding Light on the Origin of Solid-State Luminescence Enhancement in Butterfly Molecules

Different molecular strategies have been carefully evaluated to produce solid-state luminescence enhancement (SLE) in compounds that show dark states in solution. A set of α-phenylstyrylarene derivatives with a butterfly shape have been designed and synthesised, for the first time, with the aim of improving the solid-state fluorescence emission of their parent styrylarene compounds. Although these butterfly molecules are not fluorescent in solution, one of them (1,2,4,5-tetra(α-phenylstyryl)benzene) exhibits a fluorescence quantum yield as high as 68 % in a drop-cast sample and 31 % in its crystalline form. In contrast, 1,3,5-tris(α-phenylstyryl)benzene and 4,6-bis(α-phenylstyryl)pyrimidine do not show SLE. A range of fluorescence spectroscopy experiments and DFT calculations were carried out to unravel the origin of different photophysical behaviour of these compounds in the solid state. The results indicate that a rational strategy to control the SLE effect in luminogens depends on a delicate balance between molecular properties and inter-/intramolecular interactions in the solid state.

Small molecules that protect against β-amyloid-induced cytotoxicity by inhibiting aggregation of β-amyloid

Aggregated β-amyloid (Aβ) plays crucial roles in Alzheimer's disease (AD) pathogenesis, therefore blockade of Aβ aggregation is considered as a potential therapeutic target. We designed and synthesized small molecules to reduce Aβ-induced cytotoxicity by inhibiting Aβ aggregation. The small molecules were screened via ThT, MTT, and cell-based cytotoxicity assay (Aβ burden assay). Selected compounds 1c, 1d, 1e, and 1f were then investigated by evaluating their effects on cognitive impairment of acute AD mice model. Learning and memory dysfunction by injection of Aβ(1-42) was recovered by administration of these molecules. Especially, 1d showed the best recovery activity in Y-maze task, object recognition task, and passive avoidance task with dose dependent manner. These results suggest that 1d has high potential as a therapeutic agent for AD.

Synthesis and characterization of novel para- and meta-phenylenevinylene derivatives: Fine tuning of the electronic and optical properties of conjugated materials

We report the synthesis of novel phenylenevinylene derivatives that allow for the introduction of meta versus para connections on the phenylene rings, as well as the incorporation of nitrogen atoms within the conjugated backbone and the attachment of elec

Quaternary ammonium salt-assisted synthesis of extended π-systems from methyldiazines and aromatic aldehydes

4-Methyl- and 4,6-dimethylpyrimidines, methyl- and 2,5-dimethylpyrazines, as well as 3-methylpyridazine readily react with aromatic aldehydes in a hot solution of sodium hydroxide in the presence of a catalytic amount of a quaternary ammonium salt and in

Studies on Pyrimidine Derivatives. XVIII. Reaction of Active Methyl Groups on Pyrimidine N-Oxides

Knoevenagel-type condensation and the Mannich reaction were investigated with various pyridine N-oxides having an active methyl group.For example, 6-methyl-4-phenylpyrimidine 1-oxide (Va) readily reacted with benzaldehyde in an aqueous ethanolic solution