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Usage

Uses

Used in Pharmaceutical Applications:
4-(2-Pyridyl)-3-thiosemicarbazide is used as a pharmaceutical agent for its reported antimicrobial and anti-tumor activities. Its unique structure allows it to target specific biological pathways, making it a promising candidate for the development of new drugs to combat various diseases.
Used in Analytical Chemistry:
4-(2-Pyridyl)-3-thiosemicarbazide is used as a chelating agent for various metal ions. Its ability to form stable complexes with metals makes it a valuable tool in analytical chemistry for the detection, separation, and quantification of metal ions in different samples.
Used in Metal Extraction Processes:
In the field of metallurgy, 4-(2-Pyridyl)-3-thiosemicarbazide is used as a reagent for metal extraction. Its chelating properties enable the selective separation and recovery of valuable metals from complex mixtures, improving the efficiency and sustainability of metal extraction processes.
Used in Corrosion Inhibition:
4-(2-Pyridyl)-3-thiosemicarbazide is used as a corrosion inhibitor in various industrial applications. Its ability to form protective layers on metal surfaces helps prevent corrosion and extends the service life of equipment and structures exposed to harsh environments.
Used in Synthesis of Heterocyclic Compounds:
In organic chemistry, 4-(2-Pyridyl)-3-thiosemicarbazide serves as a key intermediate in the synthesis of various heterocyclic compounds. Its unique structure and reactivity make it a versatile building block for the development of new compounds with potential applications in pharmaceuticals, materials science, and other fields.

Upstream product

• 504-29-0 2-aminopyridine 
• 75-15-0 carbon disulfide 
• 149487-84-3 N-2-pyridinyl-1H-imidazole-1-carbothioamide 
• 13037-46-2 pyridin-2-yl-dithiocarbamic acid methyl ester 

Downstream Products

• 171781-96-7 4-(2-pyridyl)-1-salicylaldehyde-3-thiosemicarbazone 
• 66243-84-3 N-(α-pyridyl)benzaldehyde thiosemicarbazone 
• 1293389-48-6 N-phenyl-2-(2-(pyridin-2-ylcarbamothioyl)hydrazinyl)-2-thioxoacetamide 
• 66243-86-5 N₁-phenyl-N₂-(pyridin-2-yl)hydrazine-1,2-bis(carbothioamide) 

Relevant academic research and scientific papers

Carbazole-based semicarbazones and hydrazones as multifunctional anti-Alzheimer agents

With the aim to combat a multi-faceted neurodegenerative Alzheimer’s disease (AD), a series of carbazole-based semicarbazide and hydrazide derivatives were designed, synthesized and assessed for their cholinesterase (ChE) inhibitory, antioxidant and biometal chelating activity. Among them, (E)-2-((9-ethyl-9H-carbazol-3-yl)methylene)-N-(pyridin-2-yl)hydrazinecarbothioamide (62) and (E)-2-((9-ethyl-9H-carbazol-3-yl)methylene)-N-(5-chloropyridin-2-yl)hydrazinecarbothioamide (63) emerged as the premier candidates with good ChE inhibitory activities (IC50 values of 1.37 μM and 1.18 μM for hAChE, IC50 values of 2.69 μM and 3.31 μM for EqBuChE, respectively). All the test compounds displayed excellent antioxidant activity (reduction percentage of DPPH values for compounds (62) and (63) were 85.67% and 84.49%, respectively at 100 μM concentration). Compounds (62) and (63) conferred specific copper ion chelating property in metal chelation study. Molecular docking studies of compounds (62) and (63) indicate strong interactions within the active sites of both the ChE enzymes. Besides that, these compounds also exhibited significant in silico drug-like pharmacokinetic properties. Thus, taken together, they can serve as a starting point in the designing of multifunctional ligands in pursuit of potential anti-AD agents that might further prevent the progression of ADs. Communicated by Ramaswamy H. Sarma.

CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF

The present application relates to novel semicarbazones and thiosemicarbazones, to processes for preparing them, to pharmaceutical preparations comprising them, to the use of the novel semicarbazones and thiosemicarbazones for treatment and/or prophylaxis of diseases and to the use thereof for production of a medicament for treatment and/or prophylaxis of diseases, especially of neurodegeneration and age-associated diseases or conditions associated with NAD loss. The present application also provides a method for high throughput screening of NMNAT2 activators.

5-Nitrofuran-2-yl derivatives: Synthesis and inhibitory activities against growing and dormant mycobacterium species

Eighteen 5-nitrofuran-2-yl derivatives were prepared by reacting 5-nitro-2-furfural with various (sub)phenyl/pyridyl thiosemicarbazide using microwave irradiation. The compounds were tested for their in vitro activity against tubercular and various non-tubercular mycobacterium species in log-phase and 6-week-starved cultures. Compound N-(3,5-dibromopyridin-2-yl)-2-((5-nitrofuran-2-yl)methylene)hydrazinecarbothioamide (4r) was found to be the most potent compound (MIC: 0.22 μM) and was 3 times more active than standard isoniazid (INH) and equally active as rifampicin (RIF) in log-phase culture of Mycobacterium tuberculosis H37Rv. In starved M. tuberculosis H37Rv, 4r inhibited with MIC of 13.9 μM and was found to be 50 times more active than INH and slightly more active than RIF.

Platinum (IV) thiohydrazide, thiodiamine and thiohydrazone complexes: A spectral, antibacterial and cytotoxic study

Some platinum (IV) complexes [Pt(L)2Cl2] [where, L = 2-aminopyridine-N-thiohydrazide (L1), (2-aminopyridine-N-thio)-1,3-propanediamine (L2), benzaldehyde-2-aminopyridine-N-thiohydrazone (L3) and salicylaldehyde-2-aminopyrtidine-N-thiohydrazone (L4)] have been synthesized. The thiohydrazides, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N-S ligand. The ligands found to act in monobasic bidentate fashion. Analytical data reveals that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and 1H NMR spectroscopic studies. In vitro antibacterial and cytotoxic study have also been carried out for some complexes.

Synthesis and glucose-6-phosphatase inhibitory activity of (thiouriedo)alkanoic acid esters

A series of (3-pyridin-2-yl-thiouriedo)alkanoic acid esters (5a-j) have been synthesized by the reaction of pyridin-2-yl-dithiocarbamic acid methyl ester (2) and amino acid esters (4). Most of the synthesized compounds have been evaluated against glucose-6-phosphatase enzyme but only four compounds (5g-j) displayed significant inhibitory activity of the enzyme.

Herbicidal 1-pyridyltetrazolinones

Herbicidal tetrazolinone derivatives of the formula: STR1 in which R1 is alkyl, haloalkyl, cycloalkyl, alkenyl, haloalkenyl, alkynyl or phenyl, and R2 is alkyl, haloalkyl, cycloalkyl, alkenyl, haloalkenyl, alkynyl or phenyl, or R1 and R2 together with the nitrogen atom to which they are bonded form an optionally benzofused heterocyclic ring, which is optionally substituted by C1-4 alkyl, n is 0, 1, 2 or 3, and R3 each independently is nitro, halogen, alkyl, haloalkyl, alkylthio or phenoxy.