363-74-6

Basic information

• Product Name: 1,2-Benzenediamine, 3,4,6-trifluoro-
• CAS NO: 363-74-6
• Molecular Formula: C6H5F3N2
• Molecular Weight: 162.114
• Mol File: 363-74-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-Benzenediamine, 3,4,6-trifluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzenediamine, 3,4,6-trifluoro-(363-74-6)
• EPA Substance Registry System: 1,2-Benzenediamine, 3,4,6-trifluoro-(363-74-6)

Safety Data

• Hazardous Substances Data: 363-74-6(Hazardous Substances Data)

Upstream product

• 123394-95-6 1-(2,3,5,6-tetrafluorophenyl)-2-thia-1,3-diaza-4-(trimethylsilyl)-allene 
• 314-41-0 1,2,3,5-tetrafluoro-4-nitrobenzene 
• 5415-62-3 2,3,5-trifluoro-6-nitroaniline 
• 132844-31-6 4,5,7-Trifluoro-2,1,3-benzothiadiazole 
• 361-39-7 3,4,6-trifluoro-2-nitro-aniline 

Downstream Products

• 439-16-7 5,6,8-trifluoro-2,3-diphenyl-quinoxaline 

Relevant articles and documents

Novel compounds and compositions for treating diseases asociated with protease activity

Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.

AROMATIC POLYFLUORO COMPOUNDS LVII . NUCLEOPHILIC REPLACEMENT REACTIONS OF 1,2,3,5-TETRAFLUORO-4-NITROBENZENE, 1,2,3,5-TETRAFLUORODINITROBENZENE AND 1-BROMO-2,3,4,6-TETRAFLUORO-5-NITROBENZENE

The title compounds have been treated with dimethylamine and sodium methoxide in polar solvents, and the isomer ratios of the products determined.Although attack para to the nitro group is in each case favoured over ortho, it is so by only surprisingly small factors.Structures have mostly been assigned spectroscopically, supported in one case by a chemical proof.The dinitrotetrafluorobenzene is activated sufficiently to react directly with methanol at 35 deg C, with a pseudo first order rate constant of (7 +/- 1) * 10-5 s-1.