36305-11-0

Usage

Uses

Used in Environmental and Industrial Chemistry:
2-(1,2-DITHIOLAN-3-YL)ACETIC ACID is used as a chelating agent for binding and removing heavy metals from aqueous solutions. Its ability to form stable complexes with metal ions makes it a valuable tool in environmental remediation and industrial processes to mitigate the impact of heavy metal contamination.
Used in Pharmaceuticals:
In the pharmaceutical industry, 2-(1,2-DITHIOLAN-3-YL)ACETIC ACID is utilized for its potential to bind metal ions, which can be beneficial in the development of drugs targeting metal-related diseases or conditions. Its metal-binding properties may also contribute to the creation of new pharmaceutical compounds with specific therapeutic effects.
Used in Organic Synthesis:
2-(1,2-DITHIOLAN-3-YL)ACETIC ACID serves as a building block in the synthesis of organic molecules and coordination complexes. Its unique structure and functional groups make it a versatile component in the creation of new chemical entities with potential applications in various fields, including materials science and medicinal chemistry.

Upstream product

• 195724-22-2 2-[1,2]Dithiolan-3-yl-malonic acid dimethyl ester 
• 122538-55-0 5-benzylsulfanyl-pent-2-enoic acid ethyl ester 
• 102162-40-3 3,5-bis(benzylthio)pentanoic acid 
• 122538-56-1 3,5-bis-benzylsulfanyl-pentanoic acid ethyl ester 
• 195724-20-0 Thioacetic acid S-[3-acetylsulfanyl-1-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-propyl] ester 
• 195724-21-1 2-(1,3-Bis-acetylsulfanyl-propyl)-malonic acid monomethyl ester 

Downstream Products

• 195724-23-3 [1,2]Dithiolan-3-yl-acetic acid 4-nitro-phenyl ester 
• 457631-52-6 N-[2-(4-amino-phenyl)-ethyl]-2-[1,2]dithiolan-3-yl-acetamide 
• 457631-51-5 N-(4-amino-phenyl)-2-[1,2]dithiolan-3-yl-acetamide 
• 457631-48-0 {4-[2-(2-[1,2]dithiolan-3-yl-acetylamino)-ethyl]-phenyl}-carbamic acid tert-butyl ester 
• 457631-47-9 [4-(2-[1,2]dithiolan-3-yl-acetylamino)-phenyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Site-specific protein modification by genetic encoded disulfide compatible thiols

Cysteine chemistry provides a low cost and convenient way for site-specific protein modification. However, recombinant expression of disulfide bonding containing protein with unpaired cysteine is technically challenging and the resulting protein often suffers from significantly reduced yield and activity. Here we used genetic code expansion technique to introduce a surface exposed self-paired di-thiol functional group into proteins, which can be selectively reduced to afford active thiols. Two compounds containing self-paired disulfides were synthesized, and their genetic incorporations were validated using green fluorescent proteins (GFP). The compatibility of these self-paired di-thiols with natural disulfide bond was demonstrated using antibody fragment to afford site-specifically labeled antibody. This work provides another valuable building block into the chemical tool-box for site-specific labeling of proteins containing internal disulfides.

1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS

Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.

1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS

Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.

An efficient synthetic route to 2-(1,2-dithiolan-3-yl)acetic acid. Trisnorlipoic acid and amide derivatives

A simple, efficient synthesis of 2-(1,2-dithiolan-3-yl)acetic acid from Meldrum's acid, acrolein and thioacetic acid is described. The isopropyldene 2,4-bis(acetylthio)butane-1,1-dicarboxyl formed in the three-component, single container process, can be methanolized to the corresponding dimethyl ester and then hydrolyzed, oxidized to the disulfide and decarboxylated to 2-(1,2-dithiolan-3-yl)acetic acid. The acid can be converted by conventional reagents into a variety of amide derivatives.