363138-96-9Relevant academic research and scientific papers
A new synthesis of the GPIIb/IIIa receptor antagonist SB-214857-A
Andrews, Ian P,Atkins, Richard J,Badham, Neil F,Bellingham, Richard K,Breen, Gary F,Carey, John S,Etridge, Stephen K,Hayes, Jerome F,Hussain, Nigel,Morgan, David O,Share, Andrew C,Smith, Stephen A.C,Walsgrove, Timothy C,Wells, Andrew S
, p. 4915 - 4917 (2001)
A new synthesis of lotrafiban SB-214857-A is reported. The key steps are the preparation of racemic (4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl)-acetic acid methyl ester from 2-nitrobenzyl alcohol, a resolution using an immobilised li
