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A new synthesis of the GPIIb/IIIa receptor antagonist SB-214857-A

DOI: 10.1016/S0040-4039(01)00843-7

Source and publish data:

Tetrahedron Letters p. 4915 - 4917 (2001)

Update date:2022-08-05

Topics:

Authors:

Andrews, Ian PAndrews, Ian P

Atkins, Richard JAtkins, Richard J

Badham, Neil FBadham, Neil F

Bellingham, Richard KBellingham, Richard K

Breen, Gary FBreen, Gary F

Carey, John SCarey, John S

Etridge, Stephen KEtridge, Stephen K

Hayes, Jerome FHayes, Jerome F

Hussain, NigelHussain, Nigel

Morgan, David OMorgan, David O

Share, Andrew CShare, Andrew C

Smith, Stephen A.CSmith, Stephen A.C

Walsgrove, Timothy CWalsgrove, Timothy C

Wells, Andrew SWells, Andrew S

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Article abstract of DOI:10.1016/S0040-4039(01)00843-7

A new synthesis of lotrafiban SB-214857-A is reported. The key steps are the preparation of racemic (4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl)-acetic acid methyl ester from 2-nitrobenzyl alcohol, a resolution using an immobilised li

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Full text of DOI:10.1016/S0040-4039(01)00843-7

Products guided by the article

Product name:(E)-2-[Methyl-(2-nitro-benzyl)-amino]-but-2-enedioic acid dimethyl ester

Cas No:363138-96-9

363138-96-9

R&D Labs maybe for 363138-96-9

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