363622-48-4

Basic information

• Product Name: 1,3-dibromo-5-[(diethylphosphonyl)methyl]benzene
• Synonyms: 1,3-dibromo-5-[(diethylphosphonyl)methyl]benzene
• CAS NO: 363622-48-4
• Molecular Weight: 386.02
• Mol File: 363622-48-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,3-dibromo-5-[(diethylphosphonyl)methyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dibromo-5-[(diethylphosphonyl)methyl]benzene(363622-48-4)
• EPA Substance Registry System: 1,3-dibromo-5-[(diethylphosphonyl)methyl]benzene(363622-48-4)

Safety Data

• Hazardous Substances Data: 363622-48-4(Hazardous Substances Data)

Upstream product

• 1611-92-3 3,5-dibromotoluene 
• 56908-88-4 3,5-dibromobenzyl bromide 
• 762-04-9 phosphonic acid diethyl ester 
• 145691-59-4 (3,5-dibromophenyl)methanol 
• 56990-02-4 3,5-dibromobenzaldehyde 
• 122-52-1 triethyl phosphite 

Downstream Products

• 1391994-26-5 C₄₂H₆₀Br₂S₂ 
• 1391994-27-6 C₄₃H₆₀Br₂OS₂ 
• 1391994-28-7 C₄₇H₆₂OS₂ 
• 363622-59-7 4-[(E)-2-(3,5-Dibromo-phenyl)-vinyl]-benzonitrile 
• 1268519-03-4 (2R,3R)-1,1-bis[(diphenylphosphanyl)methyl]-2,3-bis(3',5'-diphenylphenyl)cyclopropane 
• 1268519-10-3 (2R,3R)-1,1-bis(chloromethyl)-2,3-bis(3',5'-diphenylphenyl)cyclopropane 
• 1268519-09-0 (2R,3R)-2,3-bis(3',5'-diphenylphenyl)cyclopropane-1,1-dimethanol 
• 1268519-08-9 (2R,3R)-2,3-bis(3',5'-dibromophenyl)cyclopropane-1,1-dimethanol 
• 1268519-07-8 (2R,3R)-1-(ethoxycarbonyl)-2,3-bis(3',5'-dibromophenyl)cyclopropane-1-carboxylic acid 
• 1268519-05-6 (4R,5R)-4,5-bis(3',5'-dibromophenyl)-(1,3,2)-dioxathiolane-2,2-dioxide 
• 1268519-04-5 (1R,2R)-1,2-bis(3,5-dibromophenyl)ethane-1,2-diol 
• 1070240-19-5 (E)-3,5-dibromo-1-styrylbenzene 

Relevant articles and documents

Stafia-1: a STAT5a-Selective Inhibitor Developed via Docking-Based Screening of in Silico O-Phosphorylated Fragments

We present a new approach for the identification of inhibitors of phosphorylation-dependent protein–protein interaction domains, in which phenolic fragments are adapted by in silico O-phosphorylation before docking-based screening. From a database of 10 369 180 compounds, we identified 85 021 natural product-derived phenolic fragments, which were virtually O-phosphorylated and screened for in silico binding to the STAT3 SH2 domain. Nine screening hits were then synthesized, eight of which showed a degree of in vitro inhibition of STAT3. After analysis of its selectivity profile, the most potent inhibitor was then developed to Stafia-1, the first small molecule shown to preferentially inhibit the STAT family member STAT5a over the close homologue STAT5b. A phosphonate prodrug based on Stafia-1 inhibited STAT5a with selectivity over STAT5b in human leukemia cells, providing the first demonstration of selective in vitro and intracellular inhibition of STAT5a by a small-molecule inhibitor.

Photoinduced energy and electron transfer in phenylethynyl-bridged zinc porphyrin-oligothienylenevinylene-C60 ensembles

Donor-bridge-acceptor triad (Por-2TV-C60) and tetrad molecules ((Por)2-2TV-C60), which incorporated C60 and one or two porphyrin molecules that were covalently linked through a phenylethynyl-oligothienylenevinyl

Synthesis, characterization, and optical response of dipolar and non-dipolar poly(phenylenevinylene) dendrimers

New dipolar and non-dipolar poly(phenylenevinylene) dendrimers bearing electron-donating and electron-withdrawing groups have been efficiently synthesized using Heck and Horner-Wadsworth-Emmons reactions. The photoluminescence of these systems may be tuned in the blue zone by choosing the appropriate peripheral groups. Despite the meta-substitution pattern, large Stokes shifts can be observed when π-donor and π-acceptor groups are connected by a m-phenylenevinylene system.