3637-26-1Relevant academic research and scientific papers
Matrix assisted antibacterial activity of polymer conjugates with pendant antibiotics, and bioactive and biopassive moieties
Mukherjee, Ishita,Ghosh, Anwesha,Bhadury, Punyasloke,De, Priyadarsi
, p. 3007 - 3018 (2019)
Antibacterial activity against a series of potentially pathogenic bacterial strains was evaluated in both liquid and solid matrices using ciprofloxacin (a well-known fluoroquinolone antibiotic) based polymeric systems with pendant cationic charge and zwitterionic units. The ciprofloxacin containing polymeric architecture was designed to incorporate bioactive killing properties of cationic moieties, whereas biopassive activity was regulated by the bacterial cell repelling capacity of the zwitterionic group. tert-Butyl carbamate (Boc)-leucine hydroxyethylmethacrylate (Boc-Leu-HEMA), Boc-ciprofloxacin hydroxyethylmethacrylate (Boc-Cipro-HEMA) and zwitterionic sulphabetaine methacrylate (SBMA) are copolymerized, followed by deprotection of Boc groups from the copolymer under acidic conditions. Boc deprotection resulted in water soluble polymers with cationic charge from the leucine moiety and retained the antibiotics in their active original form. The antibacterial activity of the polymeric system was evaluated against several bacterial species, namely, Escherichia coli (E. coli), Bacillus subtilis (B. subtilis), Staphylococcus aureus (S. aureus), Vibrio alginolyticus (V. alginolyticus), and Vibrio chemaguriensis Iso1 (V. chemaguriensis), in both liquid and solid matrices. The copolymer displayed significant bactericidal efficacy against non-biofilm forming E. coli and B. subtilis in both liquid and solid matrices. However, the antibacterial effect on biofilm forming V. chemaguriensis was comparatively less prominent in the liquid matrix. Optical microscope images of Gram staining revealed an enhanced surface area of individual cells and chain formation in cells of V. chemaguriensis. The non-cytotoxic profile of the polymer towards mammalian red blood cells (RBCs) and enhanced bactericidal effect in the physiological to basic pH (7.0-9.5) range against potentially pathogenic V. chemaguriensis using a multitude of microscopic techniques hinted toward the need to develop new antibiotics to combat possible clinical infections in the near future.
Synthesis method of SPE
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Paragraph 0007; 0023-0030, (2019/01/17)
The invention discloses a synthesis method of SPE. The synthesis method of the SPE comprises the following steps: mixing an organic solvent, dimethylaminoethyl methacrylate and a polymerization inhibitor uniformly, adding 1,3-propane sulfonolactone dropwise into the mixed liquid and performing reaction to obtain a target product, wherein the organic solvent is an alcohol and/or ketone solvent. According to the synthesis method, the alcohol and/or ketone solvent serves as a reaction solvent, the solvent has low toxicity and low harm, the alcohol and ketone solvents are easy to recycle and reuse, and the synthesis method is safer and more environmentally-friendly compared with the method using carbon tetrachloride as the solvent; the dimethylaminoethyl methacrylate and the 1,3-propane sulfonolactone serve as the raw materials, and the polymerization inhibitor is added, so that polymerization of the dimethylaminoethyl methacrylate can be effectively inhibited, other side reaction in the reaction process is reduced, the reaction is conducted completely, the yield of products is increased and the purity of the products is improved.
Zwitterionic copolymer-based and hydrogen bonding-strengthened self-healing hydrogel
Liu, He,Xiong, Chunming,Tao, Zhen,Fan, Yujiao,Tang, Xiaofen,Yang, Haiyang
, p. 33083 - 33088 (2015/04/27)
Self-healing systems that can spontaneously repair their damage would significantly improve the safety and prolong the lifetime of man-made materials. As external energy or healing agents are required in most of the self-healing approaches, non-covalently cross-linked polymeric hydrogels with intrinsic healing nature have attracted much attention recently. We present here a P(AM-co-DMAPS) zwitterionic copolymer based self-healing hydrogel, where AM and DMAPS are acrylamide and 3-((2-(methacryloyloxy)ethyl)dimethylammonio)propane-1-sulfonate, respectively. The electrostatic interactions within DMAPS and hydrogen bonding between AM moieties contribute to the physical cross-linking of the polymer chains and self-healing ability of the hydrogel. The reported strategy represents a general and facile route to construct zwitterionic copolymer based self-healable functional hydrogels for potential applications in the field of enhanced oil recovery (EOR).
REACTIVE IONIC LIQUID, ION-FIXING METAL OXIDE PARTICLES USING SAME, ION-FIXING ELASTOMER, AND TRANSDUCER
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Paragraph 0094, (2015/03/03)
A reactive ionic liquid to be used as an ionic component that is contained in an ion-containing layer in a transducer arranged in contact with a high-resistance layer as a dielectric layer of the transducer, and is restrained from migrating from the ion-containing layer to the high-resistance layer on application of a voltage is provided. The reactive ionic liquid comprises an ion pair that consists of an anion and a cation. In the reactive ionic liquid, (a) the anion comprises (a1) a reactive group that consists of an alkoxysilyl group and (a2) an anionic group consisting of a carboxylate (-COO-) group or a sulfonate (-SO3-) group. (b) The cation (b1) consists of an imidazolium, ammonium, pyrrolidinium, morpholinium, or phosphonium cation, and (b2) does not comprise an N-H group or a P-H group.
Synthesis and characterization of 3-[N-(2-methacroyloylethyl)-N,N-dimethylamino]propane sulfonate and its crystal structure
Xiao, Jian,Zhang, Xiu-Qin,Wang, Kai,Chen, Qiang,Xue, Wei-Wei
, p. 3818 - 3820 (2015/12/30)
3-[N-(2-Methacroyloylethyl)-N,N-dimethylamino]propane sulfonate (DMAPS) was synthesized by the ring-opening reaction of 1,3- propanesultone, then electrophilic substitution with 2-(dimethylamino)ethyl methacrylate in the presence of acetone at 60 °C. 2-(Dimethylamino)ethyl methacrylate and a little polymerization inhibitor dissolved in acetone was added in three-necked flask, the mixture was heated to 60 °C. 1,3-Propanesultone was dissolved in acetone and then be added drop-wise into the flask over 8 h. The product was characterized by NMR and Mass spectrum. The crystal structure of 3-[N-(2-Methacroyloylethyl)-N,N-dimethylamino]propane sulfonate was investigated using X-ray diffraction and SHELXTL97 software and the result indicated that DMAPS crystallized in the orthorhombic system, space group P21/c with a = 14.6818(18), b = 7.1104(9), c = 14.9180(18) ?, V = 1548.5(3) ?3; Z = 4.
A synthetic route to sulfobetaine methacrylates with varying charge distance
Kratzer, Domenic,Barner, Leonie,Friedmann, Christian,Br?se, Stefan,Lahann, Joerg
, p. 8064 - 8071 (2015/02/02)
A general synthetic strategy is described that enables access to a library of new sulfobetaine methacrylates starting from commercially available precursors. The three-step procedure allows the distance between the quaternary amine and the sulfonate group (inner charge distance) to be varied by selecting the corresponding dibromoalkane in the first step. A key step is the final esterification, in which methacrylic acid acts as solvent as well as reagent for the zwitterionic hydroxy intermediates. Thus, it is possible to synthesize monomeric precursors with up to twelve methylene groups between the positive and the negative charge. A selection of these monomers has been successfully tested for their ability to polymerize using free-radical polymerization.
