3639-23-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-2,4-dimethylvaleric acid is used as a therapeutic agent for promoting wound healing and reducing inflammation. Its potential health benefits are attributed to its ability to enhance the skin's natural healing process and alleviate symptoms associated with inflammation.
Used in Cosmetic Industry:
In skincare products, 2-Hydroxy-2,4-dimethylvaleric acid is used as an exfoliating and moisturizing agent. Its alpha-hydroxy acid properties help remove dead skin cells, revealing a smoother and more radiant complexion. Additionally, it contributes to maintaining skin hydration, improving overall skin health and appearance.
Overall, 2-Hydroxy-2,4-dimethylvaleric acid is a versatile compound with applications in both the pharmaceutical and cosmetic industries, offering a range of benefits for skin health and therapeutic treatments.

Upstream product

• 10348-50-2 2-Hydroxy-2,4-dimethyl-pentansaeure-aethylester 
• 151-50-8 potassium cyanide 
• 108-10-1 4-methyl-2-pentanone 
• 135415-90-6 (R)-2-hydroxy-2,4-dimethylpentanenitrile 
• 3639-23-4 2-hydroxy-2,4-dimethylpentanoic acid 
• 10348-48-8 ethyl 2-hydroxy-2,4-dimethylpent-4-enoate 
• 4131-68-4 2-hydroxy-2,4-dimethylpentanenitrile 

Downstream Products

• 3639-23-4 (S)-2-hydroxy-2,4-dimethylpentanoic acid 

Relevant academic research and scientific papers

METHOD FOR SYNTHESIZING ENANIOMERICALLY PURE N-(PYRIDIN-4-YL)-2-HYDROXY-ALKYLAMIDE DERIVATIVES

The present invention relates to a novel process for preparing enantiomerically pure compounds of N-(pyrid-4-yl)-2-hydroxyalkylamide type corresponding to the general formula (C) below: and also to processes for preparing the reaction intermediates used i

Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen

An efficient route to (S)-N-(2-bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide 1, a new topical antiandrogen, is described. The target compound has been manufactured on kilogram scale with an overall yield of 25% (HPLC purity 98.8% and >99% ee) from citrazinic acid. The key amide coupling between aminopyridine 4 and α-hydroxy-acid 6 was performed using a temporary protecting group to facilitate the acyl chloride formation. Aminopyridine 4 was manufactured from commercially available citrazinic acid via dibromide formation using phosphorus(V) oxybromide followed by mono SNAr reaction with sodium methoxide and a final Hofmann rearrangement. Enantiopure α-hydroxy-acid 6 was obtained using an enantioselective cyanosilylation followed by salt resolution with (S)-α-methyl benzylamine. The absolute configuration of compound 1 was determined with anomalous scattering and the final crystallization of API was performed after seeding a liquid-liquid mixture below the monotectic temperature and afforded a crystalline powder presenting a "desert rose" shape clusters.

Catalytic asymmetric synthesis of dihydrofurans and cyclopentenols with tertiary stereocenters

A new asymmetric synthesis of dihydrofurans and cyclopentenols has been developed and is based on the copper-catalyzed 1,2-addition of Grignard reagents to enones in combination with Sonogashira coupling/cyclization or ring-closing metathesis. By this approach, dihydrofurans with an oxygen-containing tertiary stereocenter and chiral tertiary cyclopentenols are efficiently prepared. The absolute stereochemistry of the products has been established. The copper-catalyzed 1,2-addition of Grignard reagents to enones, combined with Sonogashira coupling/cyclization or ring-closing metathesis, provides a new asymmetric synthesis of dihydrofurans and cyclopentenols. Two different kinds of dihydrofurans are obtained with medium-to-high enantioselectivities. Copyright

Enzyme-catalyzed synthesis of (R)-ketone-cyanohydrins and their hydrolysis to (R)-α-hydroxy-α-methyl-carboxylic acids

(R)-Ketone-cyanohydrins (R)-2 are obtained with high enantioselectivity from aliphatic ketones 1 and HCN in organic solvents using (R)-oxynitrilase ( EC 4.1.2.10) as catalyst. Acid catalyzed hydrolysis of the cyanohydrins (R)-2 affords the corresponding (R)-α-hydroxy-α-methyl-carboxylic acids (R)-3 without measurable racemization.