364064-17-5

Basic information

• Product Name: 3-(4-FLUOROPHENYL)-5-PYRIDINECARBOXYLIC ACID
• Synonyms: AKOS BAR-1640;3-(4-FLUOROPHENYL)-5-PYRIDINECARBOXYLIC ACID;5-(4-FLUOROPHENYL)NICOTINIC ACID;5-(4-FLUOROPHENYL)PYRIDINE-3-CARBOXYLIC ACID;3,4-9FLUOROPHENYL)-S-PYRIDINE CARBOXYLIC ACID;5-(4-Fluorophenyl)-3-pyridinecarboxylic acid;5-(4-Fluorophenyl)pyridine-3-carboxylic acid for synthesis
• CAS NO: 364064-17-5
• Molecular Formula: C₁₂H₈FNO₂
• Molecular Weight: 217.2
• Product Categories: Heterocyclic Compounds
• Mol File: 364064-17-5.mol

Chemical Properties

• Boiling Point: 415.7 °C at 760 mmHg
• Flash Point: 205.2 °C
• Appearance: /
• Density: 0.5 g/cm3 (20℃)
• Vapor Pressure: 1.17E-07mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Store below +30°C.
• PKA: 2.08±0.10(Predicted)
• CAS DataBase Reference: 3-(4-FLUOROPHENYL)-5-PYRIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-FLUOROPHENYL)-5-PYRIDINECARBOXYLIC ACID(364064-17-5)
• EPA Substance Registry System: 3-(4-FLUOROPHENYL)-5-PYRIDINECARBOXYLIC ACID(364064-17-5)

Safety Data

• Hazardous Substances Data: 364064-17-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-FLUOROPHENYL)-5-PYRIDINECARBOXYLIC ACID is used as a key intermediate in the synthesis of pharmaceutical drugs for its ability to contribute to the development of new chemical entities with potent biological activity. Its presence in drug molecules can enhance their therapeutic efficacy and selectivity, making it a valuable component in the creation of novel medications for various diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(4-FLUOROPHENYL)-5-PYRIDINECARBOXYLIC ACID is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its unique chemical structure allows for the design of effective compounds that can protect crops from pests and diseases, thereby increasing agricultural productivity and ensuring food security.
Used in Cancer Treatment Research:
3-(4-FLUOROPHENYL)-5-PYRIDINECARBOXYLIC ACID is employed as a potential therapeutic agent in cancer treatment research, given its ability to target and inhibit specific molecular pathways involved in cancer cell growth and proliferation. Its structural features enable the development of compounds with high specificity and potency, offering new avenues for the treatment of various types of cancer.
Used in Inflammation and Infection Treatment Research:
3-(4-FLUOROPHENYL)-5-PYRIDINECARBOXYLIC ACID is also used in the research and development of treatments for inflammation and infections. The presence of the fluorophenyl and pyridine groups in its structure allows for the design of molecules with anti-inflammatory and antimicrobial properties, providing new therapeutic options for the management of these conditions.

InChI:InChI=1/C12H8FNO2/c13-11-3-1-8(2-4-11)9-5-10(12(15)16)7-14-6-9/h1-7H,(H,15,16)

Upstream product

• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 1765-93-1 4-fluoroboronic acid 
• 7440-44-0 pyrographite 
• 1258269-07-6 ethyl 5-(4-fluorophenyl)nicotinate 
• 351529-23-2 (5-bromopyridin-3-yl)methyl acetate 
• 893734-77-5 methyl 5-(4-fluorophenyl)nicotinate 

Downstream Products

• 1258268-85-7 C₂₀H₁₇FN₂O 
• 1352786-55-0 1-[5-(4-fluorophenyl)pyridin-3-yl]-3-phenylprop-2-yn-1-one 
• 381684-96-4 5-(4-fluorophenyl)nicotinaldehyde 
• 85589-65-7 3-(4-fluorophenyl)pyridine 

Relevant articles and documents

Suzuki coupling reaction for the solid-phase preparation of 5-substituted nicotinic acid derivatives

The application of the Suzuki coupling reaction to the preparation of small combinatorial libraries using 5-bromonicotinic acid as a scaffold onto three different types of solid support (Wang, Rink, and BAL resin) is described. The application of the Suzuki coupling reaction to the preparation of small combinatorial libraries using 5-bromonicotinic acid as a scaffold onto three different types of solid support (Wang, Rink, and BAL resin) is described.

Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives

A series of aryl-substituted nicotinamide derivatives with selective inhibitory activity against the Nav1.8 sodium channel is reported. Replacement of the furan nucleus and homologation of the anilide linker in subtype-selective blocker A-803467 (1) provided potent, selective derivatives with improved aqueous solubility and oral bioavailability. Representative compounds from this series displayed efficacy in rat models of inflammatory and neuropathic pain.

METHOD FOR THE PRODUCTION OF NICOTINALDEHYDES

The invention relates to a method for producing nicotinaldehydes by reducing the corresponding nicotinic acid-morpholine amides.

Method for producing 5-aryl nicotinaldehydes

The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that the molar ratio between palladium and ligand is from 1:5 to 1:15 in the case of monodentate ligands and from 1:2.5 to 1:7.5 in the case of bidentate ligands.