364358-95-2

Upstream product

• 540-38-5 p-Iodophenol 
• 870-63-3 prenyl bromide 

Downstream Products

• 1208233-12-8 tert-butyl (E)-3-[4-hydroxy-3,5-bis(3-methylbut-2-enyl)phenyl]acrylate 
• 72944-19-5 artepillin C 
• 17622-86-5 4-hydroxy-3-(3'-methyl-2'-butenyl)-5-(3''-methyl-2''-butenyl)benzoic acid 
• 72944-04-8 artepillin C methyl ester 

Relevant academic research and scientific papers

Myrsinoic acid E, an anti-inflammatory compound from Myrsine seguinii

The methanolic extract of Myrsine seguinii yielded the novel anti-inflammatory compound, myrsinoic acid E (1), whose structure was elucidated to be 3,5-digeranyl-4-hydroxy benzoic acid. We synthesized 1- and its 3,5-diprenyl (2) and 3,5-difarnesyl analogu

PHENOL DERIVATIVES, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF

Disclosed are an efficient, safe process for producing artepillin C and derivatives thereof by an organic synthesis. The process comprises a step of reacting a phenol derivative with an acrylate or acrylic acid.

First total synthesis of artepillin C established by o,o′-diprenylation of p-halophenols in water

We have demonstrated that prenylation of phalophenols was dependent on the solvent effect and succeeded in o,o′-diprenylation of p-halophenols in water. Following the Mizoroki-Heck coupling of the diprenyl-piodophenol 3c with methyl acrylate and then hydr