3645-45-2Relevant articles and documents
NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
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Page/Page column 78-79, (2010/02/12)
Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
Low molecular weight inhibitors of complement proteases
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, (2008/06/13)
Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are
Pharmaceutically active compounds and methods of use
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, (2008/06/13)
New fused thiophene compounds are provided and methods of using those compounds for a variety of therapeutic indications. Compounds of the invention are particularly useful for treatment of neuropathic pain.
N - ( 2 - aryl - propionyl ) - sulfonamides and pharmaceutical preparations containing them
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, (2008/06/13)
The compounds of formula 1, wherein R and R2 are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear neutrophils (PMN leukocytes) at the inflammatory sites.
CHELATING COMPOUNDS, THEIR COMPLEXES WITH PARAMAGNETIC METALS
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, (2008/06/13)
Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with said metal ions and the physiologically compatible salts thereof, as well as the use thereof as contrast agents in the technique known as “Magnetic Resonanc
Functionalized ferrocenyldiphosphines, a process for their preparation and their use
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, (2008/06/13)
The invention relates to 1,2-ferrocenyldiphosphines which contain a functional group in the 1′ position either directly or via a bridging group, and also a process for their preparation. The compounds are important for transition metal complexes containing d-8 metals such as Rh, Ru, Pd or Ir. These transition metal complexes are widely used in the hydrogenation of organic double or triple bonds, in particular olefinic double bonds and carbon-heteroatom double bonds. The complexes are particularly suitable for enantioselective hydrogenation using chiral ferrocenyldiphosphines and corresponding prochiral unsaturated compounds. Ferrocenyldiphosphines having a functional group in the 1′ position are also important intermediates for ferrocenyldiphosphine ligands and their metal complexes of d-8 metals such as rhodium, ruthenium, palladium or iridium which are bound to inorganic polymeric supports via this functional group. These metal complexes bound to an inorganic or organic support material are likewise very suitable for the hydrogenation of organic double or triple bonds.
Process and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-a mide
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, (2008/06/13)
A process for preparing the compound of formula (1) is disclosed. STR1 The starting materials are an N-triazolylmethyl-6-aminoisoquinoline and a 4-biphenyl-2-carboxylic acid derivative.
DNA-affinic hypoxia selective cytotoxins
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, (2008/06/13)
Hypoxia selective cytotoxins having the structural formula STR1 wherein D, E, F and G, independently, are carbon or nitrogen, with the proviso that three or more of D, E, F and G are carbon; R1 and R2, independently, are selected fro
Acridine-intercalator based hypoxia selective cytotoxins
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, (2008/06/13)
Hypoxia selective cytotoxins of the general formula STR1 wherein n is from 1 to 5, and NO2 is in at least one of the 2, 4 or 5-positions of the imidazole. Such compounds have utility as radiosensitizers and chemosensitizers.
Synthesis and Characterization of Nitrato and Acetato Complexes of Dioxouranium(VI) with Disalicylaldehyde Acyl Hydrazones
Das, S.,Lal, R. A.
, p. 225 - 230 (2007/10/02)
Dioxouranium(VI) complexes of disalicylaldehyde oxaloyldihydrazone (H4A2), malonoyldihydrazone (H4B2), succinoyldihydrazone (H4C2), glutaroyldihydrazone (H4D2), adipoyldihydrazone (H4E2) and phthaloyldihydrazone (H4F2) have been synthesized from the reaction of uranyl nitrate hexahydrate and uranyl acetate dihydrate with the title ligands in alcoholic medium.The complexes have the compositions .2H2O and .C2H5OH where H4L2 = H4A2, H4B2, H4C2, H4D2, H4E2 and H4F2.The complexes have been characterized on the basis of elemental analyses, TGA, DTA, molar conductance, infrared and Raman spectral data.