3652-44-6Relevant academic research and scientific papers
Microwave-assisted one pot synthesis of N-substitued 2-methyl-1H-pyrrole-3-carboxylate derivatives without catalyst and solvent
Kan, Wei,Jing, Tao,Zhang, Xiao-Hong,Zheng, Yong-Jie,Chen, Lin,Zhao, Bing
, p. 2367 - 2376 (2016/03/01)
An efficient one-pot synthetic method for the N-substituted 2-methyl-1H-pyrrole-3-carboxylate derivatives has been accomplished via a microwave irradiation MCRs of various α-bromoacetophenone, amines, and ethyl acetoacetate without any solvent and catalys
Copper-mediated cross-coupling-cyclization-oxidation: A one-pot reaction to construct polysubstituted pyrroles
Liu, Pei,Liu, Jin-Ling,Wang, Heng-Shan,Pan, Ying-Ming,Liang, Hong,Chen, Zhen-Feng
supporting information, p. 4795 - 4798 (2014/05/06)
A novel and efficient procedure for the synthesis of polysubstituted pyrroles has been developed in this work. The polysubsituted pyrroles were synthesized directly from terminal alkenes, amines and β-keto esters through cross-coupling-cyclization-oxidation in the presence of a catalytic amount of cuprous chloride. This method provides a one-pot synthesis route from terminal alkenes to polysubstituted pyrroles for the first time and opens a new area in cuprous catalysis. The Royal Society of Chemistry 2014.
Three-component access to pyrroles promoted by the CAN-silver nitrate system under high-speed vibration milling conditions: A generalization of the Hantzsch pyrrole synthesis
Estevez, Veronica,Villacampa, Mercedes,Menendez, J. Carlos
, p. 591 - 593 (2013/02/22)
A sequential multicomponent process involving the high-speed vibration milling of ketones with N-iodosuccinimide and p-toluenesulfonic acid, followed by addition of a mixture of primary amines, β-dicarbonyl compounds, cerium(iv) ammonium nitrate and silver nitrate afforded polysubstituted, functionalized pyrroles. This one-pot, solid-state process can be considered as the coupling of an α-iodoketone preparation with a general version of the classical Hantzsch pyrrole synthesis.
Synthesis and antimicrobial activity of some 1,5-diaryl-2-methyl-3-carbethoxy-4-(4-methyl-piperazin-1-ylmethyl)-pyr roles and some 1,5-diaryl-2-methyl-3,4-di(4-methyl-piperazin-1-ylmethyl)-pyrroles
Cerreto,Scalzo,Villa
, p. 1735 - 1746 (2007/10/02)
The synthesis and anti-Candida activity of some 1,5-diarylpyrrole derivatives are reported and some structure-activity relationships are proposed.
