3654-50-0

Basic information

• Product Name: 2-Propen-1-one, 3-(3-hydroxyphenyl)-1-(4-hydroxyphenyl)-
• CAS NO: 3654-50-0
• Molecular Formula: C15H12O3
• Molecular Weight: 240.258
• Mol File: 3654-50-0.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-(3-hydroxyphenyl)-1-(4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-(3-hydroxyphenyl)-1-(4-hydroxyphenyl)-(3654-50-0)
• EPA Substance Registry System: 2-Propen-1-one, 3-(3-hydroxyphenyl)-1-(4-hydroxyphenyl)-(3654-50-0)

Safety Data

• Hazardous Substances Data: 3654-50-0(Hazardous Substances Data)

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 99-93-4 4-Hydroxyacetophenone 
• 75792-33-5 3-isopropoxybenzaldehyde 
• 4074-51-5 1-(4-isopropoxyphenyl)ethan-1-one 

Downstream Products

• 1380395-68-5 3-(3-hydroxyphenyl)-1-(4-hydroxyphenyl)pent-4-en-1-one 
• 1428324-89-3 C₁₇H₁₆N₂O₃ 
• 1362510-85-7 3-[2-(4-hydroxyphenyl)-6-phenylpyridin-4-yl]phenol 
• 73087-59-9 1-(4-hydroxyphenyl)-3-(3-hydroxyphenyl)propan-1-ol 
• 52182-14-6 3,4'-dimethoxychalcone 
• 75849-14-8 3,4'-dihydroxy-αβ-dihydrochalcone 

Relevant articles and documents

Natural product-based design, synthesis and biological evaluation of 2′,3,4,4′-tetrahydrochalcone analogues as antivitiligo agents

A bioactive component, 2′,3,4,4′-tetrahydrochalcone (RY3-a) was first isolated from Vernohia anthelmintica (L.) willd seeds, and a set of its analogs, RY3-a-1–RY3-a-15 and RY3-c were designed and synthesized. Biological activity assays showed that RY3-c exhibited better melanogenesis and antioxidant activity and lower toxicity in comparison with RY3-a and butin. Further study tests showed that RY3-c exhibited better melanogenesis activity compared with the positive control 8-methoxypsoralan (8-MOP) in a vitiligo mouse model, suggesting that RY3-c is a good candidate antivitiligo agent. Mechanistic studies showed that RY3-c could repair cell damage induced by excessive oxidative stress and may exert melanin synthesis activity in the mouse melanoma B16F10 cell line by activating the mitogen-activated protein kinase (MAPK) pathway and the upregulation of c-kit.

Triaryl Pyrazole Toll-Like Receptor Signaling Inhibitors: Structure–Activity Relationships Governing Pan- and Selective Signaling Inhibitors

The immune system uses members of the toll-like receptor (TLR) family to recognize a variety of pathogen- and host-derived molecules in order to initiate immune responses. Although TLR-mediated, pro-inflammatory immune responses are essential for host defense, prolonged and exaggerated activation can result in inflammation pathology that manifests in a variety of diseases. Therefore, small-molecule inhibitors of the TLR signaling pathway might have promise as anti-inflammatory drugs. We previously identified a class of triaryl pyrazole compounds that inhibit TLR signaling by modulation of the protein–protein interactions essential to the pathway. We have now systematically examined the structural features essential for inhibition of this pathway, revealing characteristics of compounds that inhibited all TLRs tested (pan-TLR signaling inhibitors) as well as compounds that selectively inhibited certain TLRs. These findings reveal interesting classes of compounds that could be optimized for particular inflammatory diseases governed by different TLRs.

Synthesis and biological activity of 2,4-di-p-phenolyl-6-2-furanyl-pyridine as a potent topoisomerase II poison

Dihydroxylated 2,4-diphenyl-6-aryl pyridine derivatives were simply achieved using Claisen-Schmidt condensation reaction and modified Kr?hnke pyridine synthetic method. Total forty-five compounds were designed and synthesized which contain hydroxyl groups