365441-82-3Relevant academic research and scientific papers
A novel bis-thiourea organocatalyst for the asymmetric aza-Henry reaction
Rampalakos, Constantinos,Wulff, William D.
supporting information; experimental part, p. 1785 - 1790 (2009/08/07)
A novel bis-thiourea/2,2′-diaminobinaphthalene (BINAM)-based catalyst for the asymmetric aza-Henry reaction has been developed. This catalyst promotes the reaction of N-Boc imines with nitroalkanes to afford β-nitroamines with good yields and high enantioselectivities. This catalyst has the advantage that it can be prepared in a single step from commercially available materials. A model is proposed for the catalyst action where both components of the reaction are activated simultaneously by hydrogen bonding. Regardless of the mechanism, the success of the present catalyst demonstrates the potential of bis-thioureas as an interesting class of relatively unexplored catalysts.
An expeditious one-pot synthesis of diethyl N-Boc-1-aminoalkylphosphonates
Klepacz, Anna,Zwierzak, Andrzej
, p. 1079 - 1080 (2007/10/03)
A general one-pot, purification-free synthesis of diethyl N-Boc-1-aminoalkylphosphonates has been developed. The procedure involves base-catalyzed Michael-type addition of sodium diethyl phosphite to N-Boc imines generated in situ by the action of sodium
Reductive BOC-amination of aldehydes
Bernacka, Elbieta,Klepacz, Anna,Zwierzak, Andrzej
, p. 5093 - 5094 (2007/10/03)
Base-assisted elimination-reduction of α-amidoalkyl sulfones with sodium borohydride proceeds in tetrahydrofuran at room temperature leading to the corresponding BOC-amines in good yields.
