365565-02-2 Usage
Description
PGP-4008 is a selective inhibitor of P-glycoprotein (P-gp) that does not affect the activity of multidrug resistance-related protein 1 (MRP1). It is effective in vitro and, when delivered intraperitoneally, in vivo, inhibiting tumor growth when given with doxorubicin . PGP-4008 also enhances the ability of docetaxel to inhibit growth and drive apoptosis in ovarian cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 365565-02-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,5,5,6 and 5 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 365565-02:
(8*3)+(7*6)+(6*5)+(5*5)+(4*6)+(3*5)+(2*0)+(1*2)=162
162 % 10 = 2
So 365565-02-2 is a valid CAS Registry Number.
365565-02-2Relevant articles and documents
Synthesis and Evaluation of Dihydropyrroloquinolines That Selectively Antagonize P-Glycoprotein
Lee, Brian D.,Li, Zhanjiang,French, Kevin J.,Zhuang, Yan,Xia, Zuping,Smith, Charles D.
, p. 1413 - 1422 (2004)
In a search for improved multiple drug resistance (MDR) modulators, we identified a novel series of substituted pyrroloquinolines that selectively inhibits the function of P-glycoprotein (Pgp) without modulating multidrug resistance-related protein 1 (MRP
