365565-02-2 Usage
Uses
Used in Pharmaceutical Industry:
PGP-4008 is used as a chemosensitizer for enhancing the efficacy of chemotherapeutic drugs like doxorubicin and docetaxel in cancer treatment. It helps overcome multidrug resistance by inhibiting the P-glycoprotein, which is often responsible for reduced drug accumulation and treatment failure in cancer cells.
Used in Cancer Research:
PGP-4008 is used as a research tool for studying the role of P-glycoprotein in multidrug resistance and the development of novel strategies to overcome this resistance in cancer treatment. Its ability to selectively inhibit P-gp without affecting MRP1 makes it a valuable compound for understanding the mechanisms of drug resistance and designing targeted therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 365565-02-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,5,5,6 and 5 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 365565-02:
(8*3)+(7*6)+(6*5)+(5*5)+(4*6)+(3*5)+(2*0)+(1*2)=162
162 % 10 = 2
So 365565-02-2 is a valid CAS Registry Number.
365565-02-2Relevant academic research and scientific papers
Lee, Brian D.,Li, Zhanjiang,French, Kevin J.,Zhuang, Yan,Xia, Zuping,Smith, Charles D.
, p. 1413 - 1422 (2004)
In a search for improved multiple drug resistance (MDR) modulators, we identified a novel series of substituted pyrroloquinolines that selectively inhibits the function of P-glycoprotein (Pgp) without modulating multidrug resistance-related protein 1 (MRP
