36597-16-7

Basic information

• Product Name: 3-AMINO-2-QUINOXALINECARBONITRILE
• Synonyms: 3-AMINO-2-QUINOXALINECARBONITRILE;AKOS BBS-00001446;3-Aminoquinoxaline-2-carbonitrile;2-Quinoxalinecarbonitrile, 3-aMino-;4-hydroxy-3-imino-1-oxidoquinoxalin-1-ium-2-carbonitrile
• CAS NO: 36597-16-7
• Molecular Formula: C9H6N4
• Molecular Weight: 170.17
• Product Categories: pharmacetical
• Mol File: 36597-16-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 208-210 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 381.5°C at 760 mmHg
• Flash Point: 184.5°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 5.05E-06mmHg at 25°C
• Refractive Index: 1.706
• PKA: 1.46±0.48(Predicted)
• CAS DataBase Reference: 3-AMINO-2-QUINOXALINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-2-QUINOXALINECARBONITRILE(36597-16-7)
• EPA Substance Registry System: 3-AMINO-2-QUINOXALINECARBONITRILE(36597-16-7)

Safety Data

• Hazardous Substances Data: 36597-16-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H6N4/c10-5-8-9(11)13-7-4-2-1-3-6(7)12-8/h1-4H,(H2,11,13)

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 480-96-6 benzofurazan oxide 
• 303130-80-5 4-Chloro-10H-[1,2,6]thiadiazino[3,4-b]quinoxaline 
• 23190-84-3 2-cyano-3-amino-quinoxaline-di-N-oxide 

Downstream Products

• 40254-89-5 3-chloro-2-quinoxalinecarbonitrile 
• 160315-07-1 3-chloro-1H-pyrazolo<3,4-b>quinoxaline 
• 40254-90-8 Cdk 1/5 Inhibitor 
• 160315-02-6 3-hydroxy-2-quinoxalinecarbonitrile 4-oxide 
• 17132-92-2 quinoxaline-2,3-dicarbonitrile 
• 1186469-78-2 C₂₅H₁₉N₅O₂ 
• 67568-30-3 2-Amino-3-carboxamidoquinoxaline 

Relevant articles and documents

New quinoxaline and pyrimido[4,5-b]quinoxaline derivates. Potential antihypertensive and blood platelet antiaggregating agents

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Novel Antagonists of 5-HT3 Receptors. Synthesis and Biological Evaluation of Piperazinylquinoxaline Derivatives

A series of piperazinylquinoxalines has been synthesized and studied as 5-HT3 receptor antagonists in different preparations.Antagonism to 5-HT in the longitudinal muscle of the guinea pig ileum was particularly prominent in cyanoquinoxaline de

AMINO-QUINOXALINE AND AMINO-QUINOLINE COMPOUNDS FOR USE AS ADENOSINE A2A RECEPTOR ANTAGONISTS

Compounds of the Formula (I), where W represents CH or N; and Q represents -CN, -C(=NOH)NH2, -CONHR1 or various herein described heterocyclic radicals; as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof are adenosine A2a receptor antagonists and, therefore, are useful in the treatment of central nervous system diseases, in particular Parkinson''s disease.

3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity

Starting with 3-amino-2-quinoxalinecarbonitrile 1,4-dioxide 1, a new series of quinoxaline derivatives was prepared through chemical modifications of the 2-cyano and 3-amino groups. Nitration of 3-amino-2-quinoxalinecarbonitrile 3 afforded the 7-nitro derivative 6. Diazotation of 3 gave the 3-chloro compound 9. 2,3-Quinoxalinedicarbonitrile 14 was obtained from 9. Pyridazino[4,5-b]quinoxalines 15 and 16 were prepared by condensing 14 with hydrazine hydrate. A triazolo[4,5-b]quinoxaline 18, a isothiazolo[4,5-b]quinoxaline 20 and two pyrazolo[3,4-b]quinoxalines 21 and 22 were identified. Compounds were tested as cytotoxic agents both in oxic and in hypoxic cells.