40254-90-8 Usage
Uses
Used in Pharmaceutical Industry:
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE is used as a research compound for studying the roles of Cdk1 and Cdk5 in various signaling pathways. Its ability to inhibit these protein kinases makes it a promising candidate for cancer therapy, as dysregulation of Cdks is often associated with uncontrolled cell proliferation and tumor growth.
Used in Cancer Research:
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE is used as a Cdk1/5 inhibitor for investigating the regulation of the cell cycle and its potential as a therapeutic agent in cancer treatment. By targeting Cdk1/cyclin B and Cdk5/p25, 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE can help researchers understand the mechanisms underlying cancer development and progression, ultimately leading to the development of novel cancer therapies.
Used in Drug Development:
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE is used as a lead compound in the development of new drugs targeting cyclin-dependent kinases. Its potent inhibition of Cdk1/cyclin B and Cdk5/p25, along with its selectivity, makes it an attractive starting point for the design and synthesis of more effective and selective Cdks inhibitors for cancer treatment.
Biological Activity
Inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC 50 values are 0.6, 0.4 and 1 μ M for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.
Check Digit Verification of cas no
The CAS Registry Mumber 40254-90-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,2,5 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 40254-90:
(7*4)+(6*0)+(5*2)+(4*5)+(3*4)+(2*9)+(1*0)=88
88 % 10 = 8
So 40254-90-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H7N5/c10-8-7-9(14-13-8)12-6-4-2-1-3-5(6)11-7/h1-4H,(H3,10,12,13,14)
40254-90-8Relevant academic research and scientific papers
3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity
Monge,Palop,Pinol,Martinez-Crespo,Narro,Gonzalez,Sainz,Lopez De Cerain,Hamilton,Barker
, p. 1135 - 1139 (2007/10/02)
Starting with 3-amino-2-quinoxalinecarbonitrile 1,4-dioxide 1, a new series of quinoxaline derivatives was prepared through chemical modifications of the 2-cyano and 3-amino groups. Nitration of 3-amino-2-quinoxalinecarbonitrile 3 afforded the 7-nitro derivative 6. Diazotation of 3 gave the 3-chloro compound 9. 2,3-Quinoxalinedicarbonitrile 14 was obtained from 9. Pyridazino[4,5-b]quinoxalines 15 and 16 were prepared by condensing 14 with hydrazine hydrate. A triazolo[4,5-b]quinoxaline 18, a isothiazolo[4,5-b]quinoxaline 20 and two pyrazolo[3,4-b]quinoxalines 21 and 22 were identified. Compounds were tested as cytotoxic agents both in oxic and in hypoxic cells.
Synthesis of Condensed Quinoxalines. VI. Synthesis of 1H-Pyrazoloquinoxaline N-Oxides and Related Compounds
Yoshida, Kei,Otomasu, Hirotaka
, p. 3361 - 3365 (2007/10/02)
Oxidation of 1H-pyrazoloquinoxalines (1a: R=H, 1b: R=CH3) with m-chloroperbenzoic acid (MCPBA) gave the 4-oxides (2a, b).The structures of 2a, b were confirmed by synthesis, by condensing 2-chloroquinoxaline-3-carbaldehyde 4-oxide (6) with appropri
